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Cancer Weekly

Susan Hasty, Publisher

Table of Contents . . . April 13th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Cancer Weekly | Other Publications

Brain Cancer - New tumor suppressor may play important role in deadly brain tumors

Developmental Biology - Tumorigenesis and organogenesis have shared features

Breast Cancer - First murine experimental model developed of human breast cancer

Cancer Diagnostics - TCR-V-beta FACS can identify peripheral blood TCLPD involvement

HIV/AIDS Cancer - Bone marrow features in AIDS patients characterized

Leukemia - Genes predict response of adult patients to chemotherapy

Acute Promyelocytic Leukemia - CD2 expression by APL cells linked to poor prognosis

Aging Skin - Chemopreventive effects of green tea said to delay aging of skin

Anti-Infectives - Caspofungin effective for pediatric cancer patients, bone marrow recipients

Arthritis Therapy - Methods otrexate may be lymphoma trigger in patients with highly active RA

Asbestos - Senators call for a national asbestos ban

Autoimmune Disease - Researchers say chemo drug may help people with autoimmune diseases

Bile Duct Tumors - Orphan drug designation granted for anticancer agent XL119

Bladder Cancer - Automated version of ImmunoCyt/uCyt+ bladder cancer test launched

Breast Cancer - Application submitted for approval of breast cancer diagnostic

Breast Cancer - Breast cancer vaccine well tolerated and safe in clinical trial patients

Breast Cancer - Breast cancers should be staged at the time of diagnosis

Breast Cancer - Cisplatin-based treatment is effective in locally advanced breast cancer

Breast Cancer - Conference votes on breast cancer research agenda for next 2 years

Breast Cancer - Diagnosis and treatment of breast cancer improve significantly over a decade

Breast Cancer - European launch of Faslodex reported

Breast Cancer - MUC-1 in postoperative axillary drainage may indicate a poor prognosis

Breast Cancer - NDA for radiation therapy sensitizer to be reviewed by FDA panel

Breast Cancer - PTTG mRNA expression in primary breast cancer may indicate tumor aggressiveness

Breast Cancer - Paclitaxel plus vinorelbine are moderately effective in advanced breast cancer

Breast Cancer - Pathologist input is valuable to the clinician treating breast carcinoma

Breast Cancer - Pregnancies ending in abortion do not increase breast cancer risk

Breast Cancer - Serum levels of sex hormones are not associated with breast cancer risk

Breast Cancer - Simple computer program predicts who is most at risk

Breast Cancer - Study highlights misunderstanding surrounding risks, benefits of tamoxifen

Breast Cancer - Telomere shortening occurs in some normal and malignant breast tissue

Breast Cancer - Workshop report discusses partial breast irradiation

Breast Cancer Therapy - NMU-based murine model could aid search for immune-based treatment

Cancer - Study to investigate cancer rates of wafer fabrication workers

Cancer Mortality - Lung and breast are 2003 top cancer deaths in Iowa

Cancer Prevention - Screenings urged by local colon cancer survivor

Cancer Therapy - 2-Methods oxyestradiol targets the tumor cell compartment as well as angiogenesis

Cancer Therapy - Abdominal and pelvic tumors respond to stereotactic boost irradiation

Cancer Therapy - Alanine is critical to TNP-470 specificity for methionine aminopeptidase-2

Cancer Therapy - Education and research are needed to improve cancer survival in Japan

Cancer Therapy - Maxim Pharmaceuticals reacquires rights to MX2105, cancer drug candidate

Cancer Therapy - Merix Bioscience announces cancer vaccines agreement

Cancer Therapy - New Panzem formulation in phase I trial

Cancer Therapy - Oral bioavailability may make idarubicin appropriate for treating older patients

Cancer Therapy - Some patients with porphyria have an increased incidence of cancer

Cancer Therapy - Survivin knockdown reduces the clonogenic survival of sarcoma cells without p53

Carcinogens - Some bacterial toxins could cause cancer

Cell Proliferation Disorders - Positive clinical results reported on oral delivery of Neugene antisense drug

Chronic Hepatitis C - Interferon improves survival in HCV patients by negating liver-related death

Cloning - Alternative to embryonic stem cell research offered

Collaborations - Material transfer agreement signed with National Cancer Institute

Collaborations - Technology that appears to arrest uncontrolled cancer growth licensed

Colon Cancer - MTHFR C677T A1298C polymorphisms may predict risk of colon cancer

Colon Cancer - Survey reveals disconnect between knowledge, action on colon cancer screening

Colorectal Cancer - ARK5 overexpression may signal progression of colorectal cancer

Colorectal Cancer - Simple changes may help improve colorectal cancer screening rates

Complementary & Alternative Medicine - Chinese herbal medicine credited with successful lung cancer treatment

Cutaneous Lymphoma - HLA-G and IL-10 may contribute to disease severity

Diagnostics - IMPATH announces distribution agreement for QCA system

Diagnostics - LYVE-1 antibody recognizes lymphatic vessels in normal and pathological tissues

Diet & Nutrition - Boosting vitamin D levels may help prevent breast cancer, study suggests

Drug Delivery - Research aims to make smart drugs that deliver the right kind of punch

Drug Development - Conjugation with geldanamycin augments Herceptin antitumor activity

Drug Development - Epidermal growth factor receptor is a modern target for treating cancer

Drug Development - Mutant B-Raf peptide shows promise as anti-melanoma immunotherapy

Dry Mouth - Salagen 7.5 mg tablet introduced

Finance - Biotechnology company announces adoption of 10b5-1 trading plans

Finance - Cancer-drug maker reports increased net loss for fourth quarter, year

Finance - Cancer-drug maker reports increased revenues and decreased losses

Finance - ImClone gets $250M related to FDA approval of ERBITUX

Finance - Institutional investors increase stake in maker of carbohydrate-based drugs

Finance - Protein-based biopharmaceutical company reports 2003 financial results

Fitness & Wellness - New York City launches program to improve residents' health

Gastric Cancer - Laparoscopy-assisted subtotal gastrectomy is effective early gastric cancer

Gastroenterology - 5-Fluorouracil and interferon gene therapy diminish colon cancer metastasis

Gastroesophageal Cancer - Tezacitabine program to be discontinued based on phase II trial analysis

Gene Expression - NCI awards grant for gene expression research

Gene Silencing - Preclinical research focuses on gene silencing against malignancy gene

Genomics - The Genome Institute of Singapore adopts MAUI Hybridization System

Genomics - University of Southern California selects REPLI-g technology

Gynecology - Downregulated HtrA1 gene changes the phenotype of ovarian cancer

Gynecology - THY1 correlates with tumor suppression in human ovarian cancer

HIV/AIDS Cancer - Anti-HHV-8 therapy effective against multicentric Castleman disease

Hematology - Downregulated ERK protein kinase prevents myeloma from secreting VEGF

Hematology - Survivin suppression halts the growth of aggressive non-Hodgkin's lymphoma

Hodgkin Disease - HDT+ASCT not effective for patients with relapsed, refractory HD

Human Papilloma Virus - MVA-HPV-IL2 vaccine shows activity in phase II HPV clinical trial

Immunology - Aquaporin expression by lymphocytes and DCs identified, characterized

Immunology - Chemokine gene modification of dendritic cells improves antitumor activity

Intracranial Meningiomas - The dural tail of intracranial meningiomas can be seen on FLAIR images

Kaposi Sarcoma - Inflammatory cytokines may aid KSHV latency

Kaposi Sarcoma - Novel immunoassay distinguishes KS from mimics

Leukemia - Adaphostin and similar agents arrest VEGF receptor tyrosine kinases

Leukemia - St. John's wort may compromise cancer drug's ability to prevent relapse

Leukemia Therapy - Leukemic RNA-pulsed DCs induce anti-AML cytotoxic activity in vitro

Leukemia Therapy - Post-remission mobilization yields valuable DC precursors

Leukemia Therapy - RIC SCT during imatinib-induced remission can resolve CML in blast crisis

Liver Cancer - Cancer treatment given to first phase III patient

Lung Cancer - Grade 1 or 2 lung cancers are minimally invasive

Lung Cancer - Phase II study of Tarceva initiated in non-small cell lung cancer patients

Lung Cancer - Quality-of-life measures are important in clinical trials of lung cancer

Lung Cancer - Video-assisted thoracic surgery is beneficial for older patients

Lymphoma Diagnostics - Distinct immunohistochemical features of pediatric BL and DLBCL identified

Medical Marijuana - Spokespeople sought to endorse marijuana in variety of medical applications

Melanoma - Childhood exposure to UV light may begin malignant transformation of cells

Melanoma - Patient education has reduced melanoma in Australia

Melanoma - Vitiligo linked to enhanced tumor control in rats

Mesothelioma - Report says asbestos deaths growing into epidemic

Neuroscience - Irregular Id protein expression correlates with neural tumor progression

Neuroscience - Local intracerebral microinfusion improves survival in glioblastoma models

Nicotine Addiction - Rimonabant helps smokers quit while limiting post-cessation weight gain

Non-Small Cell Lung Cancer - Chemoradiation with third-generation agents is promising for NSCLC

Non-Small Cell Lung Cancer - Induction chemotherapy and radiotherapy are useful for inoperable NSCLC

Non-Small Cell Lung Cancer - Newer chemotherapy for NSCLC only slightly improves survival

Non-Small Cell Lung Cancer - Platinum agents are the usual first-line treatment for advanced NSCLC

Non-Small Cell Lung Cancer - Radiation delivery approaches for lung cancer are improved

Non-Small Cell Lung Cancer - Radiotherapy and chemotherapy are the standard of care in locally advanced NSCLC

Non-Small Cell Lung Cancer - Treatment for advanced non-small cell lung cancer is often palliative

Non-Small Cell Lung Cancer - Using novel drugs to treat non-small cell lung cancer in the elderly is feasible

Oncology - CXCR2 inhibition ends lung cancer angiogenesis and proliferation

Oncology - Cytokine gene therapy staunches murine melanoma

Oncology - Lamivudine prevents hepatitis B virus reactivation in cancer patients

Oncology - Platelet integrin alpha2 marks the efficacy of angiogenesis inhibitor E7820

Oncology - Programmed cell death 4 enhances cancer's response to chemotherapy

Oncology - Recombinant BCG DNA vaccines and gene immunotherapy treat bladder cancer

Pediatric Oncology - Researchers find less toxic treatment safe for children with cancer

Personnel - Fred Vitale named vice president, business development

Prostate Cancer - Low awareness of prostate cancer among African American men, survey shows

Prostate Cancer - New molecular-based method can assess protein expression in prostate cancer

Prostate Cancer - Patients who don't smoke live longer

Prostate Cancer - Sodium butyrate and tributyrin are effective in vivo in prostate cancer

Proteomics - Bcl-X-L helps cells resist death under hypoxic conditions

Psoriasis - License agreement signed for Interleukin 20

Public Health - Survey reveals low awareness of prostate cancer among African-American men

Radiation Sickness - ImmuneRegen gets guidance from FDA and Division of Counter Terrorism officials

Radiotherapy - Stress-responsive promoters leave cells vulnerable to radiation therapy

Skin Cancer - Aesthetic reconstruction of the nose requires careful planning

Skin Cancer - Facial reconstruction techniques after skin cancer ablation are presented

Skin Cancer - Mohs micrographic surgery is effective in managing skin cancer

Skin Cancer - Peripheral in-continuity tissue examination is useful to remove cutaneous tumors

Skin Cancer - Skin cancer often presents reconstructive challenges

Skin Cancer - Women's Dermatologic Society promotes skin cancer awareness and prevention

Skin Damage - Scientific team develops new measurement for antioxidant sun protection

Small Cell Lung Cancer - Molecular targeted therapies for small cell lung cancer are being studied

Stem Cell Research - Thalidomide targets bone marrow angiogenesis in multiple myeloma patients

Stem-Cell Transplantation - Murine marrow cellularity characterized

Testicular Cancer - Testicular cancer patients need information about sexual concerns

Uterine Cancer - Estrogen and progesterone receptors predict progression of uterine tumors

Women's Health - Women with DCIS need to be better educated about treatment choices

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