Developmental Biology

Tumorigenesis and organogenesis have shared features

Published in Cancer Weekly, April 13th, 2004

A new study provides critical new insight into the shared mechanisms of normal organ development and solid tumor formation.

By studying the cerebellum (the structure in the brain largely responsible for coordinating motor activities) Drs. Alvin Kho, Isaac Kohane, David Rowitch, and colleagues at the Children's Hospital and Dana-Farber Cancer Institute in Boston have developed a novel method for comparing the genetic changes associated with normal development in mice with that of the most common malignancy of the pediatric nervous system, medulloblastoma.

"With information derived from the Human Genome Project we now have the ability to easily compare...

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Source: Cancer Weekly (2004-04-13)

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