Cancer Weekly

Bladder Cancer - Intra-arterial chemotherapy relieves symptoms of advanced bladder cancer

Oncogenesis - Group of proteins can turn cancer on or off, depending on circumstances

Endometrial Cancer - Active lifestyle reduces risk of most common gynecologic malignancy

Enzymology - Matrix metalloproteinase-8 plays a key role in cancer metastasis

Obesity Survival & Mortality - Obesity increases risk of many cancers

Adverse Drug Effects - Flutamide produces liver toxicity and a death in Germany

Adverse Drug Effects - Tamoxifen might stimulate the growth of PCDGF/GP88-positive breast cancer

Aging - Calorie restriction extends lifespan, reduces cancer

Allergy & Immunology - Lymphocyte transformation test useful to determine occupational hazards

Analgesia - Analgesic therapy may offer protection against bladder cancer

Anemia - Anemia among cancer patients can be treated with human erythropoietin

Angiology - Contrast agent concentration in mouse blood used to determine tumor vascularity

Angiology - Early ligation of inferior pancreaticoduodenal artery reduces blood loss

Angiology - Sinusoidal capillarization is distinct from angiogenesis in benign liver tumors

Asthma - Data supports benefits of second-generation immunomodulatory oligonucleotides

Biological Therapy - Altered Rho GTPase signaling pathways potential target for breast cancer therapy

Biological Therapy - Silenced clusterin-apolipoprotein J gene causes cancer cells to implode

Bladder Cancer - Form of vitamin E appears beneficial in reducing cancer risk

Bladder Cancer - New phase II/III Bexidem trial launched

Brain Cancer - Erthropoietin improves learning and memory impairment after brain irradiation

Brain Cancer - Invisible light and special goggles may improve brain tumor surgery

Brain Tumors - Brain tumor patients may present with headache

Brain Tumors - EGF gene may be therapy target and prognostic marker for glioblastoma

Breast Cancer - Androgen receptor polymorphism alters breast cancer risk in hormone therapy

Breast Cancer - Angiogenesis gene linked to biomarkers of tumor-cell growth

Breast Cancer - Breast pain as the only presenting symptom is rarely associated with cancer

Breast Cancer - Circulating tumor cells in breast cancer reviewed

Breast Cancer - Cystic hypersecretory breast lesions encompass a spectrum of pathologic lesions

Breast Cancer - Elliptical MammoSite balloon catheters receive FDA marketing clearance

Breast Cancer - Emmprin enhances several malignant properties of cancer cells

Breast Cancer - FDA clears to market breast cancer assessment applications

Breast Cancer - Fulcrum mammography film digitizer and technology issued two U.S. patents

Breast Cancer - Higher levels of certain proteins may have diagnostic use for breast cancer

Breast Cancer - Many women covered by Medicare are not having mammograms

Breast Cancer - Minimally invasive breast cancer treatment shows promise

Breast Cancer - New contrast agent aids MRI detection of lymph-node metastases

Breast Cancer - New findings published on treatment for late-stage breast cancer

Breast Cancer - New sponsor announced for 2004 Komen Race for the Cure Series

Breast Cancer - New tumor marker discovered

Breast Cancer - Prune cAMP phosphodiesterase binds nm23-H1 and promotes breast cancer metastasis

Breast Cancer - Regulatory approval sought for use of Taxotere in early stage breast cancer

Breast Cancer - Rho GTPases represent signaling convergence points and relay switches

Breast Cancer - Sentinel node biopsy may avoid complete lymph node dissection in breast cancer

Breast Cancer - Survey reports fall in stem cell transplants for breast cancer

Breast Cancer Prognosis - Poor responsiveness of breast cancer to chemotherapy explained by profile

Breast Cancer Prognosis - p53 expression does not play role in recurrent breast cancer

Breast Cancer Therapy - Bispecific antibody MDX-H210 with filgrastim highly effective in early trials

Breast Cancer Therapy - Exemestane and aromatase inhibitors play role in breast cancer management

Business Update - Genomics company "sharpens" focus, announces layoffs; CEO to retire

Cancer - European patent grants claims covering vascular targeting agent technology

Cancer - Proteins exploit disorderliness to perform a variety of different jobs

Cancer Fraud - Woman says she faked daughter's cancer to keep husband from leaving

Cancer Metastasis - Ezrin may promote tumor metastasis

Cancer Prevention - West Virginia University cancer program gets top rating

Cancer Risk - Studies fail to find link between cancer and a common fried food chemical

Cancer Risk Factor - Human papillomavirus infects all ages of women in Nigeria

Cancer Therapy - Chemotherapy of anaplastic oligodendroglial tumors outlined

Cancer Therapy - Company reports additional positive data from MBT-0206 phase I trials

Cancer Therapy - Conjugates containing HPMA copolymer and TNP-470 target tumor angiogenesis

Cancer Therapy - Expanded roles for checkpoint kinases suggest target modification

Cancer Therapy - Multimodality therapy for rectal cancer led to massive iliac artery bleeding

Cancer Therapy - New radiation treatment system installed at UC Davis Cancer Center

Cancer Therapy - Oocytes from children and young adults undergoing radiation can be preserved

Cancer Therapy - Thrombospondin-1 predicts how tumors respond to low-dose cyclophosphamide

Cancer Vaccine - Exosomes act as potent cell-free peptide-based vaccines

Cancer Vaccine - High efficiency of low-affinity epitopes in cancer therapy reported

Cancer Vaccine - Natural killer T-like cells induced by thymoma expressing alpha-fetoprotein

Cancer Vaccine - Peptide-based vaccines for cancer immunotherapy reviewed

Carcinoma - Adverse prognosis for renal cell carcinoma resection with esophageal metastases

Cerebrovascular Diseases - Endovascular treatment is feasible for some cerebrovascular diseases and tumors

Cervical Cancer - Researchers involve underserved women in a cervical cancer prevention trial

Cervical Cancer - User-friendly recruitment strategy increased prevention study participation

Chemoresistance - Genomic alterations make cells more or less resistant to drug therapy

Chronic Lymphocytic Leukemia - Geldanamycin and herbimycin A make leukemia cells sensitive to chemotherapy

Chronic Myelogenous Leukemia Therapy - Cytogenetic CE alone does not reduce post-SCT imatinib efficacy

Cognition - Cognitive dysfunction and subjective complaints of cancer patients studied

Colon Cancer - Beta-catenin may indirectly impact colorectal tumor progression or dormancy

Colon Cancer - Bilateral adrenal metastasis from colorectal cancer should be managed surgically

Colon Cancer - CPMP recommends approval of Erbitux

Colon Cancer - Existing therapies applied to new use in broader spectrum of cancer care

Colon Cancer - Researchers discover novel gene profile that may identify colon stem cells

Colon Cancer - Study reveals 52 differences in protein expression using DIGE technology

Colon Cancer - Urokinase plasminogen activator is increased during colon tumor transformation

Colorectal Cancer - A new gene for familial cancer is found

Colorectal Cancer - FDA issues approval for colorectal cancer diagnosis and treatment system

Complementary & Alternative Medicine - Many Taiwanese homebound cancer patients use complementary therapy

Diagnostic Imaging - High-field MRI provides a wealth of information when contrast is used

Diagnostic Imaging - Synchronous lymphoma and renal cell carcinoma may not be so rare

Diagnostic Imaging - Triple fusion reporter vectors identify gene expression in living subjects

Diagnostics - Prior biopsy scheme impacts pathologic features of cancers on repeat biopsies

Diagnostics - The relationship between diet and cancer is evaluated in 10 European countries

Diet & Nutrition - Dietary energy restriction may prevent skin carcinogenesis

Drug Delivery - B12 influences NF-kB survival signaling and antitumor activity of Apo2L/TRAIL

Drug Development - Fatty acid pathway, glucose combine to produce triacetic acid lactone

Drug Development - Human anti-neuroblastoma antibody cloned

Drug Development - Novel C-10 non-acetal trioxane dimers show antimalarial, anticancer activity

Drug Development - Pharmaceutical firm awarded SBIR grant for antibody development

Drug Discovery - Research collaboration to study matrix metalloprotease inhibitors

Drug Resistance - Cancer-altered apoptosis leads to tumor progression and therapy resistance

Drug Resistance - Interleukin-6 stimulates a protein known to cause chemoresistance

Drug Resistance - MUC1 transforming protein confers resistance to genotoxic anticancer agents

Endocrinology - PPAR-delta regulates intestinal adenoma growth in mice

Endocrinology - Role of CREB in CCAAT/enhancer-binding protein beta gene described

Environmental Toxins - Early exposure to environmental agents predicts adult tumors in animals

Enzymology - Aminopeptidase A is a functional vascular target

Esophagoscopy - Diagnostic Trans-Nasal Esophagoscope with Slide-On EndoSheath System CE Marked

Ewing Sarcoma - Long-term follow-up necessary for non-metastatic Ewing sarcoma

Finance - Biopharmaceutical company announces sale of common stock

Finance - Cell-therapy company raises $10.7 million in series B financing

Finance - KRX-101 maker reports decreased net loss for year

Gastric Cancer -  H. pylori CagA proteins may raise risk of gastric cancer in East Asians

Gastric Cancer - Second-line chemotherapy contributed to favorable outcome in gastric cancer

Gastroenterology - Inducible nitric oxide synthase sensitizes colorectal cancer to radiation

Gene Analysis - Altered caveolin and thrombospondin reveal liver cancer vessel status

Gene Transfer - A new cleavage product gives real-time information about transgene activity

Gene Transfer - Vectors encoding for angiostatin and endostatin surpass single-encoded vectors

Genetic Engineering - Genetically altered mice predict toxicity for individual targeted cancer therapy

Gynecology - Nomograms help identify abnormality of ovaries during sonographic examination

Gynecology - The ceruloplasmin promoter shows an affinity for ovarian tumors

HIV/AIDS Pathogenesis - Expansion of tumor antigen-specific T cells in transgenic mice reported

Head and Neck Cancer - High rates of mitochondrial DNA instability mark squamous cell carcinoma

Head and Neck Cancer - RASSF1A hypermethylation is an early sign of thyroid cancer tumorigenesis

Hematology - New therapies help patients beat cancer-related anemia

Hematology - Thalidomide helps endothelial cells escape doxorubicin-induced apoptosis

Hematology - Unrelated bone marrow transplants treat patients with non-Hodgkin lymphoma

Hepatic Cancer - Repeat hepatectomy for recurring metastasis confers survival benefits

Hepatology - COX-2-independent mechanisms steer the growth of cholangiocarcinoma

Hodgkin Lymphoma - FDG-PET imaging should be used in staging early-stage Hodgkin lymphoma

Immunology - Chemotherapy is enhanced when used in combination with OncoVEX