Metastasis
Laminin-5 gene methylation corresponds with poor outcomes in cancer patients
Published in Cancer Weekly, April 20th, 2004
According to recent research published in the journal Cancer Research, "laminin-5 (LN5) anchors epithelial cells to the underlying basement membrane, and it is encoded by three distinct genes: LAMAS, LAMBS, and LAMC2. To metastasize and grow, cancer cells must invade and destroy the basement membrane. Our previous work has shown that epigenetic inactivation is a major mechanism of silencing LN5 genes in lung cancers."
"We extended our methylation studies to resected bladder tumors (n=128) and exfoliated cell samples (bladder washes and voided urine; n=71) and...
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Source: Cancer Weekly (2004-04-20)
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