Drug Development
Human anti-neuroblastoma antibody cloned
Published in Cancer Weekly, April 20th, 2004
"Human sera have shown antitumor effects mediated by tumor-specific immunoglobulin M (IgM) antibodies," scientists in Germany explained. "Most people who have cytotoxic serum are in good health and show no evidence of exposure to tumor antigens."
In a recent study, K. Schilbach and colleagues at the University of Tubingen "characterized the serum of a healthy female adult that was highly lytic to a neuroblastoma cell line via IgM-activated complement (>60% of malignant cells were killed during the 60-min assay)."
"Complement-dependent...
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Source: Cancer Weekly (2004-04-20)
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