Cancer Weekly
Susan Hasty, Publisher
Table of Contents . . . April 27th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Cancer Weekly | Other Publications
Cancer Therapy - Early, high-dose chemotherapy with HPCS effective for poor prognosis GCT
Cancer Therapy - INO-1001, novel inhibitor of PARP, enhances radiation sensitivity
Genomics - Distinct mechanisms lead to HPRT gene mutations in leukemic cells
Liver Cancer - Liver adenomatosis associated with diabetes phenotype
Liver Cancer - Researchers discover gene that causes liver cancer in animals
Abdominal Cancers - Selective radiation therapy to abdomen can preserve fertility
Alternative & Complementary Medicine - Study seeks breast cancer survivors to test yoga as treatment for fatigue
Angiology - Anti-angiogenic agents could affect healing after surgery
Anti-Infectives - Ciprofloxacin can prevent infection in pediatric cancer patients
Antiangiogenics - Apicidin seen to inhibit new vessels in human vascular endothelial cells
Anticancer Therapy - Preclinical data presented at AACR on anticancer agent
Antimicrobials - New steroidal dimers are antifungal and inhibit human oral and breast cancer
Apoptosis - sGITR causes cell cycle arrest leading to apoptosis in macrophages
Assisted Reproduction - Ovarian tissue banking is one option for cancer patients who want to conceive
Bacteriology - Helicobacter pylori CagA protein variation may increase risk of gastric cancer
Barrett Esophagus - European approval granted for Photobarr
Bladder Cancer - Studies: NMP22 BladderChek detects bladder cancer missed by conventional test
Brain Cancer - New clues for glioma treatment found
Brain Tumors - Endoscopic technology is being applied in neurosurgery
Brain Tumors - Equipment for less invasive neuroendoscopy is evolving
Breast Cancer - AIB1/SRC-3 deficiency suppresses breast cancer progression in mice
Breast Cancer - APC8024 immunotherapy shows long-term disease stabilization
Breast Cancer - Annual screening may not be enough for women with genetic mutations
Breast Cancer - Anticancer effects, single-dose bioavailability reported with Neugene
Breast Cancer - Association found between primary, contralateral breast cancers
Breast Cancer - Breast reconstruction in thin patients can be done with TRAM flap and implant
Breast Cancer - Drug development company selects chair for breast cancer trial
Breast Cancer - Exposure to famine associated with increased cancer risk
Breast Cancer - First 1000 patients enrolled in MammoSite patient registry
Breast Cancer - Histological margin assessment for breast cancer reviewed
Breast Cancer - Immediate mammogram reading decreases stress associated with abnormal results
Breast Cancer - New technology may be better than mammography in finding microcalcifications
Breast Cancer - Partners to develop breast cancer gene expression database
Breast Cancer - Patients with BRCA1/2 mutations likely to choose double mastectomy
Breast Cancer - Prevention and genetic testing for breast cancer vary geographically
Breast Cancer - RFA for breast cancer shows promise as minimally invasive treatment
Breast Cancer - Risk factors modify incidence of BRCA-1-related breast cancer in women
Breast Cancer - Study suggests exposure to WWII famine increases breast cancer risk
Breast Cancer - There may be no race gap in support group attendance by breast cancer survivors
Breast Cancer Risk Factor - Atypia in the assessment of breast cancer risk reviewed
Breast Cancer Risk Factor - Management of women at increased risk for breast cancer reviewed
Breast Cancer Therapy - Hellenic Cooperative Oncology Group HE 10/92 study results released
Business & Finance - Pfizer terminates NAALADase license agreement
Business Update - Genencor sells its therapeutic vaccine program in multimillion dollar deal
Cancer - Biotechnology company announces monoclonal antibody candidate
Cancer - PT-100 with chemotherapy agents shows preclinical anti-tumor activity
Cancer - Partnership plans to target cancer cells through the E2F pathway
Cancer - Pharmaceutical company summarizes cancer research data presented at meeting
Cancer - Positive pre-clinical results announced for OXi4503 in cancer models
Cancer - TLR9 agonist enhances tumor response to radiotherapy in animal model
Cancer Detection - Sentinel lymph node biopsy effective for pathologic staging of solid neoplasms
Cancer Metastasis - Mounting evidence that Ezrin promotes tumor metastasis
Cancer Pathogenesis - IGF-binding protein-4 inhibits colony formation of cancer cells
Cancer Prognosis - Laminin-5 gamma 2 predicts oral lesions at risk for tumor development
Cancer Research - Ceretek drug discovery intellectual property assets acquired
Cancer Therapy - Biotech firm reports progress in soluble T cell antigen receptor programs
Cancer Therapy - Bruceantin is active against tumors in culture and in xenograft models
Cancer Therapy - Cancer-causing HDAC isoforms discussed at 2004 AACR meeting
Cancer Therapy - Company presents data from PARP inhibitor program
Cancer Therapy - Data demonstrate IMO compounds inhibit tumor growth
Cancer Therapy - Data demonstrate vaccine technology's potential to treat/prevent cancer
Cancer Therapy - Data provide rationale for KOS-862 combination clinical trials
Cancer Therapy - Data: INGN 241 continues to demonstrate broad utility as anticancer agent
Cancer Therapy - Data: Investigational MEK inhibitor AZD6244 combats cancer growth
Cancer Therapy - Dual action anticancer drug presented at AACR conference
Cancer Therapy - Moffitt teams with genomics company to predict chemotherapy response
Cancer Therapy - NIH awards phase II SBIR grant for antioxidant research
Cancer Therapy - National Cancer Institute awards discodermolide-related grant
Cancer Therapy - New data provided on GRN163L, a telomerase inhibitor drug
Cancer Therapy - New mode for killing cancer cells described
Cancer Therapy - Positive preclinical results reported for novel pyrazole compound
Cancer Therapy - Preclinical data for oncolytic virus therapy released
Cancer Therapy - Preclinical results presented for vascular targeting agent MX116407
Cancer Therapy - Scientists overcome immune resistance in dendritic cell vaccines for cancer
Cancer Therapy - Studies initiated for PBI-1402 - results expected in 2004
Cancer Therapy - Studies: Phenoxodiol produces response and restores chemosensitivity
Cancer Treatment - University of Nebraska helps set new standards for treating cancer patient nausea
Cancer Vaccine - Designer glycopeptides for elimination of carcinomas developed
Cancer Vaccine - Exosomes transfer functional MHC class I/peptide complexes to dendritic cells
Cancer Vaccine - ISCOM-based vaccines show promise for cancer immunotherapy
Cancer Vaccine - Kunjin virus replicon vaccine protects against HPV-expressing tumor
Cancer Vaccine - New antigenic peptide encoded by several MAGE genes identified
Cancer Vaccine - Peptide that mediates tumor cell lysis induces cytotoxic T lymphocytes
Cancer Vaccine - Peptide vaccination induces CD4+ T cells reactive to class I tumor peptide
Chemotherapy - Cumulative etoposide doses prognostic factor for transplant-related mortality
Clinical Trials - Evaluation of published group-randomized trials show inappropriate analysis
Collaborations - HP enters partnership to further genomic discovery in life science
Collaborations - Joint research program signed with H. Lee Moffitt Cancer Center
Collaborations - Partnership to deliver tools to accelerate information-based medicine
Colon Cancer - "Virtual colonoscopy" needs to improve before widespread clinical use
Colon Cancer - C-1311 shows preclinical anticancer activity for colon cancer treatment
Colon Cancer - Calculator provides more accurate estimates of colon cancer survival
Colon Cancer - Heme iron intake is related to an increased risk of proximal colon cancer
Colon Cancer - Interim results released from phase II study of CF101
Colon Cancer - Mucin-2 protein antibody combinatorial TX1TX2T peptide mixtures
Colon Cancer - Screening can essentially prevent colorectal cancer
Colon Cancer - Total loss of hMYH function associated with colorectal cancers
Colon Tumors - Endoscopic stenting can sometimes relieve obstruction caused by colonic tumors
Colorectal Cancer - Colorectal Cancer Screening Legislation Report Card findings released
Colorectal Cancer - Data reported for new class of cancer therapeutics
Colorectal Cancer - Immunological testing for colorectal cancer is feasible
Colorectal Cancer - Keyhole surgery offers same prognosis as conventional surgery
Colorectal Cancer - Loss of insulin-like growth factor imprinting linked to colon cancer
Colorectal Cancer - Role of Wnt antagonist sFRP1 in colorectal tumorigenesis described
Complementary & Alternative Medicine - Attitudes toward alternative therapies differ by gender and onocology profession
Complementary & Alternative Medicine - Intake of antioxidants in coffee, wine, and vegetables add to plasma carotenoids
Complementary & Alternative Therapy - In Norway, few oncologists are keen on complementary/alternative medicine
DNA Repair - Grape seed procyanidin extract prevents DNA lesions in hepatocytes in vitro
Diagnostics - Bacteria encoding light-emitting proteins allow tumor visualization
Diagnostics - Improving technique lowers complications of ureteroscopy for upper tract disease
Diagnostics - Multispectral analysis allows quantification of tumor populations
Diagnostics - PET scanning for pediatric oncology patients is explored
Diagnostics - PET-CT for pediatric oncology is implemented in a tertiary care center
Diagnostics - Retrograde ureteropyelography demonstrates fibroepithelioma of left ureter
Diagnostics - SPE-LC-ESI MS/MS method rapid and sensitive detection of CAP in seafood
Diagnostics - Thorough training necessary for endorectal ultrasound-guided biopsy
Drug Delivery - "Tandem technology" delivers two drugs simultaneously into cancer cells
Drug Delivery - Novel, small peptide, GA3, has potential as drug delivery ligand
Drug Delivery - PVD-conjugated superoxide dismutase potential renal drug carrier
Drug Discovery - Geron announces telomerase licensing agreement
Drug Resistance - Pheophorbide is specific probe for measuring ABCG2 function and inhibition
Environmental Pollutants - Organic pollutants detected in giant mussels off the Chilean coast
Esophageal Cancer - Researchers describe guidelines for Barrett esophagus screening
Finance - Cancer-therapeutics company files shelf registration statement
Finance - Diabetes management company reports 2003 financial results
Finance - Oncology products developer completes $45M Series C financing
Finance - Pharmaceutical company reports 2003 financial results
Finance - Pharmaceutical firm raises $43M; updates progress on AP23573
Finance - Pharmacogenomics firm closes series A financing round
Gallbladder Cancer - Surgery for gallbladder cancer generally has a poor prognosis
Gastric Cancer - Endoscopic mucosal resection for gastric epithelial neoplasms described
Gastric Cancer - Evidence that chronic inflammation causes cancer
Gastrointestinal Cancer - Study reports quality of life of Chinese patients with newly diagnosed GI cancer
Gastrointestinal Tumors - Endoscopic surgery can be used for palliative treatment of GI tumors
Gene Expression - CD43 involved in nuclear signaling and cell proliferation via beta-catenin
Gene Expression - Extracellular signals regulate nucleocytoplasmic shuttling of signal transducers
Gene Expression - Ku86 levels correlate with magnitude of radiation-induced lymphocyte DNA breaks
Gene Expression - TRAF3 required for signaling by LMP1 but not CD40 in B cells
Gene Mutations - USC awarded $3.5 million to study DNA enzyme
Genotyping - Hepatitis B virus genotypes compared in Japan
Growth Factors - ADAM10 and ADAM17 crucial in ectodomain shedding of six EGFR ligands
HIV/AIDS Cancer - Nadir B-cell counts correlated with Kaposi sarcoma risk
HIV/AIDS Cancer - Serum samples preferable for PCR-based Kaposi sarcoma diagnosis
Head and Neck Cancer - Advexin Clinical Data presented at AACR
Head and Neck Cancer - Radiation impacts quality of life in head and neck cancer patients
Hepatitis B Virus - HBV genomic variability not seen to exacerbate chronic hepatitis B
Human Papillomavirus Vaccine - Immunogenicity against HPV enhanced by Salmonella enterica phenotype
Immunology - ImmuneRegen establishes research entity in Singapore
Intrahepatic Stones - Debris left in IHBD may be a cause of postoperative stone formation
Leukemia - Company completes NDA for clofarabine
Leukemia - Hematopoietic reserve evaluated in B-CLL patients
Leukemia - Molecular analyses of leukemia patients suggest strategies for better treatments
Leukemia - Phase II trial of BCX-1777 initiated in T cell leukemia
Leukemia - Study expands on effectiveness of AP23464, in Gleevec-resistant leukemia cells
Leukemia Therapy - Post-HSCT dendritic cell recovery kinetics determined
Licensing Agreement - P&GP to develop RDP58 for gastrointestinal disorders
Liver Tumors - Laparoscopic right hepatectomy is feasible
Lung Cancer - Combining scans improves radiologists' targeting of lung tumors
Lung Cancer - Positive results reported from phase IIb BLP25 liposomal vaccine trial
Lung Cancer - Telcyta phase III registration trial initiated in NSCLC
Lung Cancer - Tobacco use fingered as culprit in lung cancer increase in women
Lymphoma - Complete remission feasible in HIV NHL patients
Malaria Therapy - Artemisinin can augment effects of anti-leukemia drugs
Medicare - CMS adds to list of outpatient services eligible for additional payments
Melanoma - CancerVax announces presentation of phase II data on Canvaxin
Melanoma - Scientists discover SSX, a new family of cancer vaccine targets
Melanoma - Sentinel lymph node biopsy useful for melanoma prognosis
Melanoma - Sentinel node biopsy for melanoma is an accurate prognostic indicator
Melanoma Therapy - New treatments for melanoma at distant metastases being developed
Melanoma Vaccine - gp100209-2M peptide vaccine induces immune response in melanoma patients
Meningiomas - Researchers give guidelines for ligating the sigmoid or transverse sinus
Mergers & Acquisitions - Assets of OpTx Corporation acquired
Metalloproteinases - MMPs degrade certain macromolecules, which may have a role in tumor invasion
Molecular Diagnostics - PGP9.5 mRNA contributes to medullary thyroid carcinoma molecular-based diagnosis
Molecular Virology - p185/Cu17-binding-defective Tag mutants unable to transform fibroblasts
Multiple Myeloma - Phase III pivotal trial for STR begins
Mycology - Pulmonary cryptococcosis presents as solitary focal ground-glass opacity on HRCT
Myelodysplasia - New test shows promise for diagnosing myelodysplasia
Myelodysplastic Syndromes - Results reported from Dacogen phase III study in myelodysplastic syndromes
Myeloid Leukemia - Cloretazine studied for acute myeloid leukemia or myelodysplastic syndromes
Nasal Abnormalities - Researchers present a classification scheme for congenital nasal anomalies
Nutrition - Dietary heme iron and zinc alter risk of proximal and distal colon cancers
Nutrition - Fortifying soymilk has potential to improve vitamin D intake in college students
Oncogenesis - CBP loss causes T cell lymphomagenesis in synergy with p27(Kip1) insufficiency
Oncogenesis - Received truth turned on end in cancer research
Oral Cancer - Overexpression of COX-2 is associated with radioresistance in oral SSC
Ovarian Cancer - Agreement signed for phase III Xyotax trial
Ovarian Cancer - Dendritic cell stimulation restores ovarian-tumor-specific cytotoxicity
Pancreatic Cancer - FDA accepts Orathecin New Drug Application for filing
Pancreatic Cancer - Survival rates after pancreatic cancer surgery are often overestimated
Pancreatitis - Pancreatic involvement in systemic sarcoidosis with high serum amylase/lipase
Personnel - Biopharmaceutical company names new senior VP of clinical development
Personnel - Biotechnology company appoints new member to the board of directors
Personnel - Drug discovery company names interim chairman of the board
Product Licensing - Agreement inked for development of pharmacogenomic diagnostic assays
Product Line Expansion - Med-Design acquires Low Profile Safety Huber Needle
Prostate Cancer - E-cadherin is important in prostate cancer cell invasion
Prostate Cancer - Nerve-sparing radical retropubic prostatectomy is used widely
Prostate Cancer - Prostate tumors treated with antiandrogens can become hormone refractory
Prostate Cancer - Spousal social control efforts have a negative effect on men with prostate cancer
Prostate Cancer - Study says frequent sex doesn't increase prostate cancer risk
Prostate Cancer - Taxane-based therapy reduces pain and increases survival in HRPC
Prostate Cancer - cPSA test with digital rectal exam recommended for prostate cancer diagnosis
Prostate Cancer Therapy - Delivery system for leuprolide developed to treat prostate cancer
Proteomics - Role of ClpX AAA+ ATPase in engagement of protein substrates described
Radioimmunotherapy - Trivalent fusion protein for radioimmunotherapy developed
Renal Cell Cancer - Positive rhLF cancer results presented at AACR meeting
SARS - NCI collaboration to investigate role of ACE2 in SARS
Secondhand Smoke - New study adds weight to link between passive smoking and death
Skin Cancer - Dose-dependent risk of skin cancer with occupational exposure to UV radiation
Skin Cancer - Fresh apple peel extract may have potential chemoprotective effects
Skin Neoplasia - Plastic surgeons need more knowledge of pathology guidelines of skin neoplasia
Solid Tumor Cancers - Novel anti-cancer drug data presented at cancer research meeting
Solid Tumors - Phase I trial of XIAP initiated
Stem-Cell Research - NF-kappaB/Rel-mediated apoptosis regulation reviewed
Surgical Technique - EUS-FNA sensitive and specific alternative to surgical procedures
Surgical Techniques - Nasal stent improves surgical reconstruction success of rhinectomy
Surgical Techniques - Remote thermometry increases safety in radiofrequency ablation
T Cell Lymphoma - HuMax-CD4 gets fast track status
Tongue Cancer - Embryonal rhabdomyosarcoma of the tongue reported in elderly man
Tumor Suppressor Gene - Phagocytosis of necrotic cells does not induce inflammatory cytokine production
Tumors - Oncology compounds identified for further development
Ulcerative Colitis - Suspected role of Helicobacter in colitis studied
Ureteroscopy - The use of ureteroscopic surgery is expanding
Ureteroscopy - With increased use, complications of ureteroscopy are possible
Urinary Tract Cancer - Ureteroscopic treatment of some urinary tract cancers is feasible
Urological Cancer - Researchers discuss techniques of nerve-sparing pelvic surgery
Ventriculostomy - Endoscopic third ventriculostomy is feasible for aqueductal stenosis
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