Cancer Pathogenesis
IGF-binding protein-4 inhibits colony formation of cancer cells
Published in Cancer Weekly, April 27th, 2004
According to recent research published in the journal Cancer Research, "Effects of insulin-like growth factor-binding protein-4 (IGFBP-4) on proliferation, colony formation, and cell migration were assessed in IGF-sensitive and -insensitive colorectal cancer cell lines. In IGF-insensitive Isreco-1 cells, overexpression of IGFBP-4 reduced colony formation but not cell proliferation and migration, whereas exogenous IGF-II had no effect. In IGF-dependent LS1034 cells, IGFBP-4 inhibited all parameters of growth tested, whereas IGF-II...
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Source: Cancer Weekly (2004-04-27)
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