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Lymphoma Therapy

Allo-PBSCT with RIC feasible for children with refractory Hodgkin disease

Published in Cancer Weekly, May 4th, 2004

Allogeneic PBSCT with reduced intensity conditioning is feasible and effective for children with treatment-resistant HD.

"Despite high-dose chemotherapy and autografting, the outcome for patients with primary refractory Hodgkin's disease (HD) or multiple relapses remains unsatisfactory," hematologists in Germany explained.

In a study conducted by A. Claviez and colleagues at the University of Kiel, "[s]ix pediatric patients (median age: 16 years, range: 11-19) received reduced intensity conditioning and allogeneic peripheral blood stem-cell transplantation (PBSCT) after failure of stratified first-line chemotherapy, involved-field radiotherapy, and...

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