Published in Cancer Weekly, May 4th, 2004
Recently published data show that "the U leader exon located within the 5' untranslated region of Epstein-Barr nuclear antigen 1 (EBNA1) gene contains an internal ribosome entry site (IRES) element. Sequence analysis of the U leader exon was undertaken in samples from 19 patients with infectious mononucleosis and 19 patients with lethal lymphoproliferative diseases and in 15 spontaneously established lymphoblastoid cell lines," wrote investigators in Japan.
"The sequence was conserved except for a single base substitution (T-C) at...
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