Oncogenesis

Oncogenesis from single base mutation in IRES of Epstein-Barr nuclear antigen 1

Published in Cancer Weekly, May 4th, 2004

Oncogenesis develops from a single base mutation in the internal ribosome entry site of Epstein-Barr nuclear antigen 1.

Recently published data show that "the U leader exon located within the 5' untranslated region of Epstein-Barr nuclear antigen 1 (EBNA1) gene contains an internal ribosome entry site (IRES) element. Sequence analysis of the U leader exon was undertaken in samples from 19 patients with infectious mononucleosis and 19 patients with lethal lymphoproliferative diseases and in 15 spontaneously established lymphoblastoid cell lines," wrote investigators in Japan.

"The sequence was conserved except for a single base substitution (T-C) at...

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Source: Cancer Weekly (2004-05-04)

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