Cancer Vaccine

Dendritic cell subsets induce antigen-specific cytotoxic T cell responses

Published in Cancer Weekly, May 4th, 2004

Dendritic cell subsets generated from CD34+ hematopoietic progenitors can be transfected with mRNA and induce antigen-specific cytotoxic T cell responses.

"Human dendritic cells (DCs) generated in culture from either monocytes or CD34+ hematopoietic progenitor cells (CD34-HPCs) have been used in cancer immunotherapy protocols with encouraging results. Yet an optimal strategy for the delivery of antigen to DCs still remains to be established. Recent studies demonstrated the feasibility of mRNA transfection to load monocyte-derived DCs," scientists writing in the Journal of Immunological Methods report.

"It is not known, however, whether DCs...

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Source: Cancer Weekly (2004-05-04)

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