Cancer Weekly
Susan Hasty, Publisher
Table of Contents . . . May 11th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Cancer Weekly | Other Publications
Acute Myeloid Leukemia - Genetic screening study identifies most aggressive adult leukemia strains
Bone Marrow Transplant - Re-immunization after bone marrow transplantation discussed
Cancer - Patent issued for anti-cancer compound Xanafide amonafide
Colorectal Cancer - Clinical practice guidelines updated
Thyroid Cancer - A multidisciplinary approach is necessary when treating thyroid cancer
Adrenocortical Cancer - Steroidogenic acute regulatory therapy useful for adrenocortical cancer
Angiology - Rare solitary floating vena caval thrombi curable if diagnosed early
Antimicrobials - Marine sponge constituent cribrostatin 6 bactericidal against S. pneumoniae
Bacterial Genetics - In vivo expression technology identifies virulence genes in H. pylori
Bacterial Toxin - Small molecule inhibitors found active against anthrax lethal factor
Bladder Cancer - Bortezomib combines with gemcitabine to combat human bladder tumor growth
Bladder Cancer - Eoquin anti-tumor activity studies initiated in U.S.
Bladder Cancer - Retroperitoneal lymph node dissection offers prognostic information
Bone Tumors - Myeloma bone disease destroys bone, which is not replaced
Brain Cancer - Cathepsin B inhibition suppresses angiogenesis in human glioblastoma cells
Brain Tumors - 3D MR digital subtraction angiography is useful in diagnosing brain tumors
Brain Tumors - Brain tumors may depend on multiple variables for growth that are not understood
Brain Tumors - Human alpha-lactalbumin made lethal to tumor cells kills glioblastomas
Brain Tumors - Petroleum plant exposure did not increase brain tumor mortality for workers
Breast Cancer - Breast biphasic lesions with cellular stroma difficult to diagnose
Breast Cancer - Certain compounds in beer, wine effective in slowing breast-cancer cell growth
Breast Cancer - Dedicated mammographer improves diagnosis of small breast cancer
Breast Cancer - Depressive symptoms after breast cancer surgery are common
Breast Cancer - Estrogen receptor-alpha mutation K303R not found in Japanese breast carcinomas
Breast Cancer - FDA approves computer-aided detection on digital mammography system
Breast Cancer - Focus-group intervention for breast cancer survivors and spouses decrease stress
Breast Cancer - Interleukin-8 is a key mediator of breast cancer invasion and angiogenesis
Breast Cancer - Mammaglobin may be a candidate diagnostic marker for breast cancer
Breast Cancer - Managed healthcare has an impact on breast cancer patients and providers
Breast Cancer - Perillyl alcohol suppresses breast cancer cell growth in vitro and in vivo
Breast Cancer - Physical activity reduces breast cancer risk in young women
Breast Cancer - Physicians challenged to control postmenopausal symptoms safely
Breast Cancer - Quicker testing for BRCA genes available - at a price
Breast Cancer - Researchers study the psychosocial needs of breast cancer survivors
Breast Cancer - Ring finger protein RNF11 important target for novel cancer therapies
Breast Cancer - Soft copy and hard copy readings of mammograms are typically comparable
Breast Cancer - Study: Information on cancer detection methods is confusing, misleading
Breast Cancer - Ultrasonography depicts benign and malignant lesions at mastectomy site
Breast Cancer - Women decline breast cancer trial participation out of fear
Breast Cancer Incidence - Effect of environment on breast cancer risk reviewed
Breast Cancer Prognosis - Sentinel lymph node biopsy may raise threshold for adjuvant therapy
Breast Cancer Prognosis - Urokinase-type plasminogen activator is prognostic in breast cancer
Breast Cancer Vaccine - NY-ESO-1 shows promise as antigen for breast cancer vaccine development
Business & Finance - Biotechnology company opens U.S. operation and announces new name
Cancer - Data indicate potential for Ad-IL2 cancer immunotherapy program
Cancer - Phase I clinical trial to assess intravenous VEGF trap in cancer
Cancer - Scottish government awards grant for anti-cancer antibody research
Cancer Biomarker - Squamous cell carcinoma antigen variants are overexpressed in liver cancer
Cancer Gene Therapy - Fiber-mutant adenovirus vectors have antitumor activity
Cancer Risk - Smoking linked to more than 60% of cancer deaths in black men
Cancer Therapy - Blood screen may help cancer patients thwart radiation side effects
Cancer Therapy - Drugs that target cancer angiogenesis also have a direct impact on tumor cells
Cancer Therapy - Gabapentin controls seizures in children receiving chemotherapy
Cancer Therapy - Japanese study shows drug combo can slow lung cancer
Cancer Therapy - NCI grant to help company discover second-generation Hsp90 inhibitors
Cancer Therapy - Older patients often suffer pain and fatigue after cancer surgery
Cancer Therapy - Orlistat is inhibitor of fatty acid synthase with antitumor activity
Cancer Therapy - Paper describes novel in situ cancer vaccine to cure recurrent cancer
Cancer Therapy - Prodrugs becoming an integral part of the drug discovery paradigm
Cancer Therapy - Radiation system designed to provide greater accuracy, effectiveness
Cancer Therapy - Radiation therapy can cause early or late pulmonary complications
Cancer Therapy - Specific oncosurgical therapies are not suited to outpatient clinics
Cancer Therapy - The hypoxia-inducible factor-1 inhibitor PX-478 abates large tumor growth
Cancer Treatment - Oklahoma House approves funds for cancer treatment
Cancer Vaccine - CD8+ T cells against Her-2/neu antigens possess antitumor activity
Cancer Vaccine - Tumor rejection antigen carbohydrate mimic elicits antitumor response
Cell Transduction - Intracellular MDA-7/IL-24 mediates activity in lung cancer cells
Central Nervous System Cancer - New variations of CNS neoplasms are emerging
Cervical Cancer - TriPath Imaging signs multi-year agreement for liquid-based Pap test
Chemotherapy - Coping methods vary in chemotherapy-induced alopecia
Clinical Trial - Gloucester Pharmaceuticals acquires rights to anticancer compound
Cognition - Cognitive function independent prognostic factor in survival of glioma patients
Collaborations - Agreement signed for oncology molecule
Colon Cancer - A capecitabine regimen is effective in advanced or metastatic colorectal cancer
Colon Cancer - Biallelic MYH mutations confer susceptibility to colorectal cancer
Colon Cancer - Company licenses new colon cancer gene
Colon Cancer - Hormone modifications due to pregnancy may reduce colon cancer risk
Colon Cancer - Unlikely protein boosts metastatic colon cancer growth
Colorectal Cancer - Prescribing increase expected for Avastin colorectal cancer therapy
Colorectal Cancer - Racial disparity in deaths equalized by insurance coverage
Colorectal Cancer - Thymidylate synthase expression not linked to colon cancer phenotype
Complementary & Alternative Medicine - Flavenoids from Scutellaria plants inhibit cancer cell proliferation in vitro
Complementary & Alternative Medicine - Several Chinese medicinal herbal extracts are strong angiogenesis modulators
Complementary & Alternative Medicine - Wikyungtang herb inhibits proliferation of lung cancer cells in vitro
DNA Replication - Research reported on DNA replication and repair
Diagnostic Imaging - Ultrasound analysis of breast cancer vascularization predicts patient survival
Diagnostics - 11C-choline PET useful to diagnose tumors in nasal cavity, paranasal sinuses
Diagnostics - MastaScope launched at European Breast Cancer Conference
Diagnostics - Primovist, a new MRI liver-contrast agent, approved in Sweden
Diagnostics - Reactive oxygen species level determines cell susceptibility to apoptosis
Diagnostics - Relative tumor area predicts nonsentinel node metastases and recurrence
Dietary Supplements - First study of resveratrol finds effect on breast, prostate cancers unlikely
Drug Development - 2-Methoxy- and 2-ethyl-estrogen sulfamates curtail angiogenesis in vitro
Drug Development - Aaptamine derivatives show antitumor and antimicroibal activity
Drug Discovery - Challenges of virtual screening for kinase targets demystified
Drug Mechanisms - Curcumin induces apoptosis via impairment of the ubiquitin-proteasome system
Drug Resistance - Companies team to offer ABC transporter assays
Drug Toxicity - Local renal production of chloroacetaldehyde causes nephrotoxicity
Drug Toxicity - Subchronic toxicity from enzymatically decomposed rutin not observed in rats
Endocrinology - Menin inactivation leads to parathyroid tumorigenesis
Environmental Health - Solvent, common drug identified as endocrine disruptors
Environmental Toxins - Feds pick up pace of Hanford payments
Enzymology - Sphingomyelinase activity modulates the development of lethal hepatitis
Estrogen Replacement Therapy - National study shows estrogen-alone has both risks and benefits
Finance - Biopharma company offers up to 4,000,000 shares of common stock
Finance - Diagnostics company announces pricing of IPO of 6 million shares
Finance - Imaging company completes restatement, files audited statements for 2000-2003
Finance - Renagel maker reports financial results for first quarter
Gastric Cancer - Alpha-fetoprotein correlates with the metastatic status of gastric carcinoma
Gastric Cancer - Insulin-like growth factor binding protein helps prevent gastric cancer
Gastrointestinal Tumors - Telomerase inhibitor PinX1 not involved in gastrointestinal tract carcinoma
Gene Induction - The introduction of VEGFR2 fragments into tumors slows their growth
Genomics - Collaboration with p53 and p63, p73 responds to cell genotoxic damage
Genomics - Endostatin stalls angiogenesis with a complex network of control signals
Genomics - LCR promotes beta-globin transcription repression in committed cells
Glioblastoma - Lack of brain specific angiogenesis inhibitor-1 in brain tumors forecasts death
Head And Neck Cancer - Late effects of neck irradiation described
Head and Neck Cancer - Hypoxia bridges vascular and hypoxia-related cytokines in human oral cancers
Head and Neck Cancer - Surgical management of head and neck malignancy reviewed
Hepatitis B - New data support Hepsera's long-term efficacy against chronic hepatitis B
Hormone Therapy - Biases in Million Women Study explain discrepant observations
Immunology - Immunoregulatory role of B7-H1 reviewed
Immunology - Interleukin-10-related cytokines and their receptors are therapeutic targets
Immunotherapy - Cancer immunotherapy and heat-shock proteins reviewed
Information Technology - Link recognized between Internet use and cancer outcome
Kaposi Sarcoma - Sirolimus effective for treatment of post-transplant KS
Laryngeal Nerve Paralysis - Recurrent laryngeal nerve paralysis usually results from surgery or neoplasia
Leukemia - Flourine compounds toxic to human leukemic cells
Leukemia - Localization of SART3 tumor antigen by monoclonal antibody reported
Leukemia - Myeloablative therapy for chronic myelogenous leukemia alters vascularity
Leukemia - New target blocks B-ALL, boosts Gleevec's effectiveness against CML in mice
Leukemia - PNP inhibitor BCX-1777 use reduces leukemic T cells
Leukemia Diagnostics - RQ-PCR WT1 assay useful for minimal residual disease monitoring
Leukemia Therapy - Treatment options for adult T-cell leukmia reviewed
Liver Cancer Therapy - Vesicular stomatitis virus infusions staunch hepatocellular carcinoma in rats
Lung Cancer - Gefitinib shows promise in treating non-small cell lung cancer
Lung Cancer - Molecular footprints may gives clues about human lung cancer progression
Lymphangiogenesis - Microenvironmental factors govern the character of sentinel lymph nodes
Lymphoma - Celiac disease is not associated with lymphoma risk
Lymphoma - Chlamydiae infection may be associated with ocular adnexal lymphoma
Lymphoma Therapy - CHOP-R therapy feasible during PBSC mobilization
Malignant Melanoma - National Cancer Institute grant to fund phase II study of INGN 241
Melanoma - Dendritic cells in tumor sites linked to control of metastatic melanoma
Melanoma - Patients with multiple primary melanoma have INK4A mutations
Melanoma - Unusual angiomatoid metastatic melanoma described
Melanoma Vaccine - IL-2 improves metastatic malignant melanoma response to vaccine
Melanoma Vaccine - Production of melanoma gp100 antigen and polyclonal antibodies reported
Mesothelioma - German tumor registry shows asbestos present in most mesothelioma patients
Metastasis - Discovery sheds light on how cancer cells grow and divide
Metastasis - Molecular assessments of sentinel nodes augment gastrointestinal cancer exams
Metastasis - Paradigm of metastasis for melanoma and breast cancer developed
Molecular Biology - DNA computers could control gene expression
Molecular Virology - Promoter activity of AVL-A LTR region related to induction of glial neoplasm
Multiple Myeloma - Phase II trial to evaluate Xcellerated T cells in relapsed multiple myeloma
Mutagenesis - FGFR3 and P53 mutations affect pathogenesis of urothelial cell carcinoma
Mutagens - Mutagenicity of cooking oil fumes reduced by adding antioxidants
Mutations - CHEK2*1100delC mutation has no major contribution in esophageal carcinogenesis
Nasopharyngeal Cancer - High-dose 3D re-irradiation benefits nasopharyngeal cancer patients
Nausea - Phase I trial of APF530 initiated as adjunct to chemotherapy
Neoplasia - Canine breast tumors overexpress vascular endothelial growth factor receptor
Oncogenesis - Hepatitis B virus preS1 sequences stimulate squamous cell carcinoma antigen
Oncogenesis - Specific hepatitis B virus mutations predict liver cancer formation
Oncology - Endothelin and its receptors signal the malignant potential of breast lesions
Oral Cancer - Alcohol is associated with the development of oral cancer
Oral Cancer - Dental school survey shows dental hygienist's role in catching cancer
Oral Cancer - Thallium-201 SPET is better than CT/MRI in finding recurrent oral cancer
Osteosarcoma - Her-2 and EGFR are osteosarcoma vaccine targets
Ovarian Cancer - Enrollment complete for phase III trial of Actimmune plus standard therapy
Ovarian Cancer - High-volume hospitals result in improved survival from ovarian cancer in Japan
Oxidation - High-dose chromium induces apoptosis; low-dose activates antioxidant system
Pancreatic Cancer - Cancer testis antigens show promise for pancreatic carcinoma treatment
Pancreatic Cancer - Metastatic/examined lymph node ratio is important prognostic factor
Pancreatic Cancer - Pancreatic cancer remains a disease with poor survival
Pancreatic Cancer - Study shows opioid growth factor safe cancer therapy
Patents - Company announces issuance of second Cardiosonix patent
Personnel - Hospira announces board of directors
Personnel - Imaging company announces retirement of CEO/chairman
Personnel - Joseph S. Mohr named president and CEO of cancer therapeutics company
Personnel - New Jersey device company names Robert G. Pinco to advisory council
Personnel - Richard Kent tapped for election to the board of directors
Personnel - Stem cell pioneer Dr. Nelson Chao named to advisory board
Personnel - Usha Arunachalam, PhD, MBA, named VP of business development
Prostate Cancer - A traditional Japanese diet may protect against prostate cancer
Prostate Cancer - Intensity-modulated radiation therapy reduces penile bulb exposure
Prostate Cancer - Novel cooperation up-regulate vitamin D receptor protein
Prostate Cancer - Suprapubic ultrasound and CT images of the prostate compared
Prostate Cancer - The androgen receptor may be a target for prostate caner therapy
Radiation Therapy - Antitumor HDAC inhibitors promote wound healing following radiation
Rectal Cancer - Spouses are supportive of partners with a stoma after rectal cancer
Skin Cancer - Aldara deemed approvable by U.S. FDA
Skin Cancer - Ultraviolet-A triggers signals linked to skin tumor promotion and progression
Soy Nutrition - FDA reviews health claim petition regarding reduction in cancer risk
Surgical Technique - Horn shaped fascio-cutaneous flap reliable for cutaneous malignancies
Survival - Standardized parotidectomy of pleomorphic adenoma minimizes tumor relapse
Teenage Smoking - Tobacco-prevention ads target teens in North Carolina
Thoracic Malignancies - Radiation therapy can cause second primary tumors
Thyroid Cancer - Higher doses of 131I in differentiated thyroid cancer may be more successful
Transfection - CXCR4 restricts adenovirus-mediated transgene expression to tumor cells
Transformation - Autocrine stimulation by osteopontin sustains carcinoma proliferation in vitro
Tumor Regulation - Vascular cytokine uses regulatory pathways to send proangiogenic signals
Tumor Suppression - Acetylation of Ku70 by CBP and PCAF controls Bax-mediated apoptosis
Tumorigenesis - Fbw7 essential in controlling cyclin E and Notch signaling pathways
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