Brain Cancer

Cathepsin B inhibition suppresses angiogenesis in human glioblastoma cells

Published in Cancer Weekly, May 11th, 2004

Cathepsin B inhibition suppresses angiogenesis in human glioblastoma cells.

According to recent research from the United States, "the cysteine proteinase cathepsin B has been implicated in tumor progression by virtue of its increased mRNA and protein levels, as well as its localization at the invading front of the tumor. In this study, we examined whether blocking cathepsin B expression in human glioblastoma SNB19 cells affects angiogenesis. Stable transfectants of human glioblastoma cells with a plasmid containing antisense cathepsin B cDNA showed decreased migration rates in wound- and spheroid- migration assays.

"Analysis showed a reduction in...

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Source: Cancer Weekly (2004-05-11)

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