Cancer Vaccine

CD8+ T cells against Her-2/neu antigens possess antitumor activity

Published in Cancer Weekly, May 11th, 2004

The CD8+ T cell repertoire against Her-2/neu antigens in neu transgenic mice is of low avidity with antitumor activity.

According to a study from the United States, "The majority of tumor-associated antigens are aberrantly expressed or overexpressed normal gene products. Therefore, mechanisms responsible for self tolerance dampen immune responses against these antigens. To evaluate the effect that tolerance has on the immune responses against tumor antigens, we characterized the CD8+ T cell responses in neu mice.

"T cell responses against the A2.1/neu p369-377 and p773-782 peptides were evaluated in neu mice that were crossed with A2.1/Kb transgenic...

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Source: Cancer Weekly (2004-05-11)

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