Diagnostics

Smac/DIABLO expression a novel prognostic marker of lung cancer

Published in Cancer Weekly, May 18th, 2004

Smac/DIABLO expression is a novel prognostic marker of lung cancer.

"Recently Smac/DIABLO (second mitochondria-derived activator of caspase) has been identified as a proapoptotic protein that inhibits IAPs (inhibitors of apoptosis proteins). Smac is expressed ubiquitously in many organs, including the lung." The "expression of Smac mRNA with real-time reverse-transcription PCR" was evaluated "in 88 primary lung cancers and matched normal tissues," scientists in Japan wrote.

"Smac mRNA expression in tumor tissues was significantly lower than that in normal tissues (p<0.0001). In squamous cell carcinomas, Smac mRNA expression was significantly lower...

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Source: Cancer Weekly (2004-05-18)

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