Liver Cancer
Overexpressed L36a gene associates with hepatocellular carcinoma proliferation
Published in Cancer Weekly, May 18th, 2004
According to a study from South Korea, "using messenger RNA (mRNA) differential display, we identified a single complementary DNA (cDNA) fragment (HG23T1) that was overexpressed in a hepatocellular carcinoma (HCC) specimen. We cloned the full-length HG23T1 gene by the rapid amplification of cDNA end (RACE) polymerase chain reaction (PCR) method. It perfectly matched the gene encoding human ribosomal protein L36a (RPL36A also referred to as RPL44).
"RPL36A mRNA was preferentially overexpressed in 34 of 40 HCC cases (85%, p<0.001) and in all of 8 HCC cell lines....
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Source: Cancer Weekly (2004-05-18)
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