Oncogenesis

Treatment targeting oncogenes could sensitize tumors to antiangiogenic agents

Published in Cancer Weekly, May 18th, 2004

Treatment targeting oncogenes could sensitize tumors to antiangiogenic agents.

According to a study from Canada, "among novel promising approaches that have recently entered the scene of anticancer therapy angiogenesis inhibition and targeting cancer-causing genes (e.g. oncogenes) are of particular interest as potentially highly synergistic.

"One reason for this is that transforming genetic lesions driving cancer progression (e.g. mutations of ras and/or p53) are thought to be causative for the onset of tumor angiogenesis and thereby responsible for build up of vascular supply which is essential for cancer cell survival, malignant growth, invasion...

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Source: Cancer Weekly (2004-05-18)

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