Cancer Weekly

Acute Myeloid Leukemia - A combined regimen is active against refractory acute myelogenous leukemia

Brain Cancer - Irinotecan plus BCNU shows low toxicity in patients with progressive glioma

Cancer Risk Factor - Nitrites consumed from animal products may increase pancreatic cancer risk

Public Health - Drinking water wells near abandoned mines need to be tested for carcinogens

AIDS/HIV Transmission - AZT causes pattern of mutations in Tk gene of mice treated as neonates

Actinic Keratosis - Phase II clinical trial of Polyphenon E Ointment begins

Addiction Research - New study to ask: Will early lung cancer detection lead to tobacco cessation?

Adverse Drug Effects - Platinum-based chemotherapy generates neurotoxicity via several mechanisms

Allergy & Immunology - Cancers with the most intense IGF-I receptor expression may be more aggressive

Animal Models - Animal models of tumor immunity and cancer vaccines reviewed

Astrocytoma - Versican G3 influences brain tumor angiogenesis and growth

Biological Therapy - Therapies that exploit heat shock protein 90 target cancer growth

Biomarker - CYR61 and CTGF have prognostic value for patients diagnosed with glioma

Bladder Cancer - Vitamin A, E, C, and selenium may help prevent and treat bladder cancer

Brain Cancer - Bone marrow-derived stem cells used for potential treatment of gliomas

Brain Cancer - Chemical brain scans may help reassure patients

Brain Cancer - Mechanism enables stem cells to track migrating brain tumor cells

Brain Tumors - Aberrant methylation can contribute to inactivation of genes in ependymal tumors

Brain Tumors - Cytometric bead analysis can measure apoptosis in glioblastoma

Breast Cancer - A major enzyme uses Src tyrosine kinase to upregulate VEGF in breast tumors

Breast Cancer - Cancerous lesions show "surprising characteristics" on MRI

Breast Cancer - Catastrophizing increases fatigue during radiotherapy for breast cancer

Breast Cancer - Childhood growth is related to breast cancer risk

Breast Cancer - Cryosurgery successfully treats some early-stage tumors

Breast Cancer - Expression profiles of 6000+ genes in normal breast cells determined

Breast Cancer - FDA issues 510k clearance for single-channel device for HDR brachytherapy

Breast Cancer - Features of invasive lobular and ductal breast carcinomas compared

Breast Cancer - Full-field digital mammography is faster for needle localization

Breast Cancer - IGF-binding protein induces apoptosis in breast cancer cells

Breast Cancer - Medullary breast cancers are not an indication for BRCA1 mutation screening

Breast Cancer - New technique allows visualization of sentinel lymph node drainage

Breast Cancer - Researchers prepare guidelines for managing familial breast cancer

Breast Cancer - South Asian women in NE England have higher mastectomy rates than non-Asians

Breast Cancer - Soy processing influences estrogen-dependent tumor growth in mice

Breast Cancer - Study evaluates quality of life of breast cancer patients 1 year after diagnosis

Breast Cancer - Study of surgical site infections in breast surgery reported

Breast Cancer - Study: MRI-guided breast biopsy system is safe, efficient

Breast Cancer - Surgical excision still necessary when core biopsy shows minimal abnormal cells

Breast Cancer - Taxanes may enhance patients' immunity

Breast Cancer Diagnostics - Tissue microarray valuable for validation of HER2 FISH testing

Breast Cancer Risk Factor - IGF expression higher in tissue of women at high breast cancer risk

Breast Cancer Survival and Mortality - Only grading has independent impact on breast cancer survival

Breast Cancer Survival and Mortality - Survival for breast cancer patients has improved in Scotland

Breast Cancer Therapy - Aromatase inhibitors show promise against postmenopausal breast cancer

Breast Cancer Therapy - Idoxifene only modestly efficacious in breast cancer patients

Breast Cancer Therapy - Optimal management of ductal carcinoma in situ of the breast described

Breast Lesions - Benign mucocele-like lesions can be differentiated from mucinous carcinoma

Cancer Diagnostics - Tissue microarray validated for immunohistochemical melanoma analysis

Cancer Genetics - Researchers confirm genetic link between hereditary breast, prostate cancer

Cancer Genetics & Genomics - Imprinting status of DLK1 gene is maintained in brain tumors and lymphomas

Cancer Inhibition - Overexpressed pigment epithelium-derived factor arrests melanoma cell growth

Cancer Prevention - Xerox gives employees paid leave for up to a year for charity work

Cancer Risk Factor - Benign thyroid disease and thyroid cancer have a hereditary foundation

Cancer Therapy - $4 million in research grants awarded

Cancer Therapy - Cancer survivors often experience discordant feelings

Cancer Therapy - Cisplatin down-regulates Janus kinase 2 in cancer cells

Cancer Therapy - Clostridia spores offer a natural alternative for tumor targeting

Cancer Therapy - Company announces positive HuMax-CD4 phase II lymphoma data

Cancer Therapy - Data published describing novel mechanism of mda-7 anticancer activity

Cancer Therapy - EGR-1 correlates with repair of lethal and sublethal lesions

Cancer Therapy - Inhibition of tumor galectin-1 gene expression promotes T cell-induced rejection

Cancer Therapy - Make-A-Wish kid debuts cancer-fighting video game

Cancer Therapy - Male fertility can be preserved during cancer treatment

Cancer Therapy - New data describe tumor-killing activity of Advexin

Cancer Therapy - New patent protects Introgen's INGN 241 cancer therapeutic

Cancer Therapy - Truncated fibroblast growth factor-2 halts tumor proliferation

Cancer Therapy - Ultrasound-guided biliary endoscopy safe and effective

Cancer Therapy - c-Rel transcription factor can transform cells to malignancy in culture

Cancer Trends - Wyoming cancer rates rise slightly

Cancer Vaccine - Immunoregulatory T cells in tumor immunity reviewed

Cancer Vaccine - Response in pRL1a multiple antigen peptide-immunized mice reported

Cancer Vaccine - T-cell vaccine improved by antigen targeting via dendritic cells

Cell Biology - Ceramide synthesis can be targeted for the treatment of cancer

Cervical Cancer - Human papillomavirus 18 and altered genes combine to form glassy cell carcinoma

Cervical Cancer - Milestone reached in use of DNAwithPap test

Cervical Cancer - Revised screening guidelines require re-education of women, physicians

Cervical Cancer - Vaginal radical trachelectomy is an alternative to radical hysterectomy

Choroidal Neovascularization - Preclinical data support anti-angiogenic effects of monoclonal antibody

Clinical Trials - Cancer therapeutics company names Jerry McMahon CEO; Jack Bowman to retire

Clinical Trials - Researchers develop optimal estimator for clinical trials

Cognition - The Wisconsin Card Sorting Test is sensitive to the effects of low-grade tumors

Collaborations - Alliance formed to advance cell signaling cancer therapeutics

Collaborations - Biorepository to be launched at Duke for clinical research in cancer

Collaborations - Cleveland Clinic inks molecular diagnostics collaboration

Colon Cancer - BRAF and KRAS gene mutations drive colorectal adenocarcinoma formation

Colon Cancer - DNA microarray analysis reveals silenced genes

Colon Cancer - Mechanism of chemoprotective action of folic acid proposed

Colon Cancer - Systemic therapies take a shot at metastatic colorectal cancer

Colon Cancer - V3D-Colon system receives FDA approval for detection of colon cancer

Colorectal Cancer - Differentially expressed genes in colorectal adenoma may help early detection

Colorectal Cancer - HMO physicians not screening all eligible patients for colorectal cancer

Colorectal Cancer - Physicians should discuss palliative care with terminal rectal cancer patients

Complementary and Alternative Medicine - Company applies for patent covering ProAlgaZyme product

Complementary and Alternative Medicine - Curcumin uses iron reduction to stimulate mitochondrial membrane permeability

Complementary and Alternative Medicine - The new plant derivative equol stops growth regulated by androgens

Cytotoxicity - Copper counteracts the toxic effects selenite has on human cancer cells

DNA Damage - Nuclear factor-kappa B regulates p53 response in DNA-injured neurons

Developmental Biology - Zebrafish useful model for human development and disease

Diagnostics - Brushings cytology results can be improved by additional review

Diagnostics - Imaging techniques increase identification of MM cytogenetic abnormalities

Diagnostics - MAUS is insufficient for routinely diagnosing transitional cell bladder tumors

Diagnostics - New imaging analysis evaluates the angiostatic activity of docetaxel

Diagnostics - Thinprep-prepared cytology comparable with conventional methods

Drug Delivery - Drugs leave brain tumors rapidly after convection-enhanced delivery

Drug Delivery - Self-assembled nanoparticles shepherd RGD peptide to tumor vessels

Drug Development -  Aloe saponaria mannan has potent anticancer effects

Drug Development - Organic copper complexes are a new class of tumor-selective inhibitors

Endocrinology - Cyclooxygenase 2 stimulates interleukin-1beta-induced angiogenesis

Endocrinology - Multiple endocrine neoplasia-associated tumors are autonomous genetic events

Endometrial Cancer - Increased plasma levels of two IGFs associated with disease risk

Endometrial Cancer - Progesterone receptor isoforms dwell in low-grade endometrial stromal sarcoma

Environmental Health - Mutations in Big Blue rats fed leucomalachite green analyzed

Environmental Health - North Dakota human services workers get new office after cancer scare

Environmental Health - Outdoor air pollution causes many cancer-related deaths in Russia

Enzymology - New findings contradict conventional views about hTERT and breast cancer

Epithelial Cancer - HER2/neu peptides recognized by cellular and humoral immune systems

Esophageal Adenocarcinoma - Rare esophageal cancer in African Americans may differ from whites