Cancer Genetics & Genomics

Imprinting status of DLK1 gene is maintained in brain tumors and lymphomas

Published in Cancer Weekly, May 25th, 2004

Study shows that imprinting of DLK1 is maintained in brain tumors and lymphomas, researchers say.

According to published research from the United States, "DLK1 and GTL2 are reciprocally imprinted genes on human chromosome 14q32. DLK1 encodes a transmembrane protein that is a paternally expressed gene. The maternally expressed GTL2 allele encodes a non-translated RNA."

"Many of features of DLK1/GTL2 are remarkably similar to those of the prototypical IGF2/H19 reciprocally imprinted gene pair. Imprinting status of IGF2 has been studied in many types of tumors, and loss of imprinting (LOI) leads to biallelic expression of IGF2 in most of these tumors....

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Source: Cancer Weekly (2004-05-25)

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