Herpesvirus

Murine herpesvirus-68 ORF73 critical for latency establishment and maintenance

Published in Cancer Weekly, June 1st, 2004

Murine herpesvirus-68 ORF73 is critical for latency establishment and maintenance.

"In vitro studies have established that the latency-associated nuclear antigen encoded by human Kaposi's sarcoma-associated herpesvirus and the related ORF73 gene product of herpesvirus saimiri interact with virus origins of replication to facilitate maintenance of episomal DNA. Such a function implies a critical role for ORF73 in the establishment and maintenance of latency in vivo," wrote scientists in the Journal of General Virology.

"To determine the role of ORF73 in virus pathogenesis, the ORF73 gene product encoded by murine herpesvirus-68 (MHV-68) was...

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Source: Cancer Weekly (2004-06-01)

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