Colon Cancer
EDTA enhances antitumor effect of cisplatin in rat colon tumors
Published in Cancer Weekly, June 8th, 2004
"We have investigated whether EDTA, a calcium chelator, could improve the accumulation of platinum in tumors and enhance the antitumor efficacy by increasing drug diffusion through the extracellular tumor matrix. Intratumoral injection of 0.3 mg/kg cisplatin combined with 10 mg/mL EDTA in 2 mL saline serum led to tumor cure in four of eight rats and produced major tumor regression in the other animals," investigators in France report.
"In contrast, intratumoral injection of cisplatin alone or EDTA alone had no antitumoral effect," said Christian Duvillard...
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Source: Cancer Weekly (2004-06-08)
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