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Study reviews the evolution of statistical methods used with clinical trials

Published in Cancer Weekly, June 8th, 2004

Researchers discuss the progress of statistical methods in relation to clinical trials, including the development of software and future trends.

"This paper describes how statistical methods have evolved in parallel with activities associated with randomized control trials," a researcher in Singapore reports.

"In particular we emphasize the pivotal role of two papers published in British Journal of Cancer, and the paper describing the Cox proportional hazards model. In addition, the importance of early papers on estimating the sample size required for trials is highlighted," wrote D. Machin, National Cancer Center, Singapore.

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