Radiation Therapy
Ceramide restoration overcomes cancer cell radioresistance
Published in Cancer Weekly, June 15th, 2004
"Recent strategies to sensitize radioresistant tumors are based on combining gamma-irradiation with inducers of apoptosis. We report that the combination of three inhibitors of sphingolipid metabolism, DL-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol.HCl(DL-PDMP) +imipramine+/-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol (D-MAPP), with 10-Gy irradiation triggers both mitotic and apoptotic killing in radioresistant SQ20B squamous carcinoma cells," investigators in France report.
"In these cells, apoptosis is defective due to a lack of ceramide generation upstream, which cannot...
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Source: Cancer Weekly (2004-06-15)
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