Published in Cancer Weekly, June 15th, 2004
According to recent research published in the Journal of Pathology, "Cyclin D1 is a target molecule transcriptionally activated by aberrant beta-catenin in Wnt signalling, while prolyl isomerase Pin1 promotes cyclin D1 overexpression directly or through accumulation of beta-catenin in cancer cells. This study aimed to elucidate whether Pin1 was involved in cyclin D1 overexpression and aberrant beta-catenin in thyroid tumorigenesis by examining 14 follicular adenomas (FAa) and 14 papillary thyroid carcinomas (PTCs)."
"All PTCs displayed cyclin D1 overexpression and strong cytoplasmic...
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