Cancer Therapy

New chemical adaptor unit releases a drug by enzymatic triggering

Published in Cancer Weekly, June 15th, 2004

Researchers develop a drug delivery system that releases drugs enzymatically.

"A new controlled drug delivery system for selective chemotherapy was developed," scientists writing in the journal Bioorganic & Medicinal Chemistry report.

"It is based on a chemical adaptor unit that releases a drug by a spontaneous cyclization mechanism after cleavage of an enzymatic substrate. It also provides a generic linkage of a drug with a targeting device in a manner set to be triggered by defined enzymatic activity," wrote A. Gopin and colleagues, Tel Aviv University.

"The system is generic and allows using a variety of drugs, targeting...

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Source: Cancer Weekly (2004-06-15)

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