Colorectal Cancer

Flavaglines induce apoptosis in colorectal cancer cells

Published in Cancer Weekly, June 15th, 2004

Flavaglines are a group of efficient growth inhibitors that block cell cycle progression and induce apoptosis in colorectal cancer cells.

According to a study from Austria, "Flavaglines are flavonol-cinnamate-derived cyclopent-a[b]benzofurans, so far reported only for the genus Aglaia of the plant family Meliaceae. They represent a group of highly bioactive metabolites already known for their strong anti-leukemic activities. To assess their suitability as chemotherapeutic drugs in colorectal cancer, their cytostatic effects and the underlying mechanisms of action were analyzed in colorectal tumor cell lines."

"Aglaiastatin was the most active...

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Source: Cancer Weekly (2004-06-15)

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