Cancer Weekly

Genomics - p16(INK4a) and p53 tumor suppressor genes altered in hTERT-immortalized cells

HIV/AIDS - AIDS-related NHL is treated traditionally as supportive care improves

HIV/AIDS Gene Therapy - TAT-pK/DNA complex useful way to package therapeutic genes for cell transduction

Head & Neck Cancer - Docetaxel is active against squamous cell carcinoma of the head and neck

Head & Neck Reconstruction - Researchers use an innovative technique for cutting the pectoralis major muscle

Head and Neck Cancer - The loss of RASSF1A expression propels nasopharyngeal cancer proliferation

Health and Fitness - Multiple myeloma patients commit to exercise based on a number of factors

Healthcare Benefits - Connecticut governor signs bill mandating wig coverage

Healthcare Policy - A rise in hepatitis C-related diseases will impact managed care in the U.S.

Heart Disease - Mammograms may help predict cardiovascular disease?

Hematology - Updated results presented from phase III study of Dacogen in MDS

Hepatocellular Carcinoma - Molecular markers evolve early in hepatitis B virus-related liver cancer

Hepatology - The transcription factors Snail and SIP1 heighten liver cancer invasion

Herpesvirus - HHV-8 vFLIP essential for survival of infected lymphoma cells

Human Antibodies - Lymphoma treatments receive EU orphan drug designation

Immune Mediated Diseases - Clinical trial of new immunomodulatory agent set to begin

Immunology - $100,000 invested in software modeling systems for inflammatory diseases

Immunology - New phase I cancer trial planned

Interfaith Intervention - Cancer program-sponsored spiritual events comfort cancer patients

Kidney Cancer - Bispecific antibody works against micrometastatic renal cell carcinoma

Kidney Transplantation - Immunosuppressants may hasten oncogenesis in patients with p53 mutations

Legal Issues - Taxol settlement brings Coloradans $430

Legal Issues - Tennessee cancer patients get $265,000 in Taxol settlement

Leukemia - Elderly patients benefit from intensive treatment

Leukemia - U.S. research hospital helps Brazilian children fight leukemia

Leukemia Therapy - Effective rituximab treatment of B-cell PLL reported

Leukemia Therapy - High CD33-antigen levels limit gemtuzumab efficacy

Liver Cancer - Novel PCR-array system useful for gene expression profiling

Liver Cancer - Utility of cryotherapy as ablative treatment evaluated

Liver Cancer Therapy - Quadruple therapy battles liver cancer on several fronts

Liver Metastasis - Epirubicin levels in liver metastases after administration reported

Liver Tumors - Liver transplantation is feasible for neuroendocrine tumors

Lung Cancer - Benefits of screening for lung cancer with CT are not proven

Lung Cancer - Enrollment completed in pivotal trial of Xyotax

Lung Cancer - Lung screening test may prove useful as first line of lung cancer testing

Lung Cancer - Matrix metalloproteinase-2 encourages pulmonary adenocarcinoma invasion

Lung Cancer - Study finds male and female smokers have similar cancer risk

Lung Cancer - Variations in DNA repair genes may predict survival in lung cancer patients

Lung Transplantation - FDG-PET scan can find post-transplant lymphoproliferative disorder

Lymphoma - Cell growth and death controlled by single pathway in cancer model

Lymphoma - Contract research organization to help develop monoclonal antibody for lymphoma

Lymphoma - FDA issues special protocol assessment for phase III trial of FavId

Lymphoma - Initial bone marrow involvement is infrequent in nasal-type NK/T cell lymphoma

Lymphoma - Minimal region of deletion implicates four genes in follicular lymphoma

Magnetic Resonance Imaging - MRI can detect primary lung tumors in rodents

Medullary Thyroid Cancer - A single, small medullary thyroid tumor does not mandate total thyroidectomy

Melanoma - Lead acetate exposure in vitro can damage melanoma cells

Melanoma - MART1/MelanA stains have high false-positive rate

Melanoma Vaccine - Melanoma vaccine based on vector of membrane fusogenic liposomes

Melanoma Vaccine - Reproductive death delayed in progeny of irradiated melanoma cells

Meningioma - Study reviews the biology, diagnosis, and treatment of meningiomas

Metastases - Metastatic potential may be a genetic feature of the primary tumor

Metastases - Researchers identify a novel target for cancer therapy

Metastasis - Antisense oligonucleotides diminish breast cancer cell migration

Metastasis - Breast metastases from extramammary malignancies are rare

Metastatic Solid Tumors - Patient treatment begins in Reolysin trial for metastatic solid tumors

Molecular Diagnostics - Molecular typing techniques are useful for detecting pathogenic fungi

Mutagenesis - PTEN gene alterations don't appear to impact synovial sarcoma prognosis

Myelodysplastic Syndromes - FDA approves Vidaza (azacitidine for injectable suspension) for MDS

Neuroblastoma - Salvage therapy influences survival in children with recurrent neuroblastoma

Neuroscience - CXCL12 supports the angiogenesis and cellular cross-talk of glioma

Neuroscience - Enzyme signals help interferon-beta stimulate glioma cell apoptosis

Neuroscience - Retrovirally mediated gas1 expression restricts glioma cell proliferation

Nicotine Addiction - List linking smoking to diseases expands

Non-Hodgkin Lymphoma - Extranodal non-Hodgkin lymphoma can occur in the sinonasal tract

Non-Hodgkin Lymphoma - FDA accepts Onco TCS new drug application

Non-Hodgkin Lymphoma - Pesticide exposure is not related to increased risk of NHL in southern Sweden

Non-Small Cell Lung Cancer - Patients with locally advanced lung cancer benefit from chemoradiotherapy

Oncogenesis - Bcl-2 suppresses senescence and programmed cell death

Oncogenesis - Cyclin-dependent kinase 4 may foster liver cancer formation

Oncogenesis - Epithelial metaplasia may be involved in antitumor immunity

Oncogenesis - Many genes synergize with Cbfb-MYH11 to produce acute myeloid leukemia

Oncology - Human prostaglandin F synthase reigns in respiratory and digestive tract tumors

Oncology - Thalidomide treats multiple myeloma by targeting bone marrow angiogenesis

Oncolysis - Peroxisome proliferator activated receptor response elements block cell death

Oral Cancer - Smoking triggers saliva's switch from hero to villian

Oral Cancer - Study finds no association between marijuana use and incidence of oral cancer

Oral Cancer - Synthetic and natural agents can cause apoptosis in oral cancer cells

Osteosarcoma - Apo2L/TRAIL and doxorubicin increases sensitivity to bone sarcomas

Ovarian Cancer - Anti-tumor responses induced by ovarian cancer protein characterized

Ovarian Cancer - Chemotherapy after cytoreductive surgery for ovarian cancer beneficial

Ovarian Cancer - GSTP1 genotypes, expression, and outcome described in ovarian cancer

Ovarian Cancer - Gonadotropin-induced gene regulation may increase cancer risk

Ovarian Cancer - Imbibing alcohol doesn't increase disease risk

Ovarian Cancer - Model prevents inaccurate surgical staging of ovarian carcinoma

Pain Medicine - Greek nurses express their knowledge of pain experiences

Pain Medicine - New developments in treatment of cancer pain reviewed

Pancreatic Adenocarcinoma - Survival after surgery for pancreatic carcinoma averaged less than 6 months

Pancreatic Cancer - Clinical trial to study Panvac-VF in advanced pancreatic cancer

Pancreatic Cancer - CyberKnife radiosurgery provides local tumor control

Pancreatic Cancer - Inactivation of Men1 gene causes pancreatic and pituitary tumorigenesis

Pancreatic Cancer - Pancreatic islet cell tumors have non-islet origin

Patents - U.S. patent granted for its Immunogene therapy for cancer

Personnel - Cancer therapy systems manufacturer adds eighth member to board of directors

Personnel - Diagnostics/research company names chief financial officer

Personnel - Molecular oncology research company names new board member

Prostate Cancer - Androgen deprivation affects thyroid function tests in prostate cancer

Prostate Cancer - Array CGH superior to standard CGH for detection of DNA loss

Prostate Cancer - CHEK2 mutation is linked to increased prostate cancer risk

Prostate Cancer - Choosing hormone therapy for prostate cancer depends on several factors

Prostate Cancer - Epidemiology of prostate cancer outlined

Prostate Cancer - Men on "watchful waiting" eligible for soy-mushroom extract trial

Prostate Cancer - Radiation after prostate cancer surgery lessens chance of recurrence

Prostate Cancer - Researchers advocate adjuvant therapy in high-risk prostate cancer

Prostate Cancer - Study finds flaws in diagnostic test

Prostate Cancer - Xanafide clinical trial commences in patients with prostate cancer

Proteomics - Kaposi sarcoma-associated herpesvirus K1 protein stimulates invasion factors

Pulmonary Medicine - Downregulated dipeptidyl peptidase IV lets non small cell lung cancer flourish

Radiation Therapy - Quinoxaline 1,4-dioxides potentiate the effects of ionizing radiation

Radiology - X-ray beams trigger potent therapy against cancer

Radiotoxicity - COMP-Ang1 protects endothelial cells from radiation-induced apoptosis

Ribosome - Decreased repeat lengths encourage transgene stability after transfection

Skin Cancer - More UVA than UVB fingerprint mutations in basal layer of human squamous tumors

Skin Cancer - More countries adopt WHO standards for UV radiation exposure

Spinal Cord Gangliogliomas - Surgical outcome is generally favorable for spinal cord gangliogliomas

Stem-Cell Research - Embryonic stem cells are an alternate marrow donor source

Stem-Cell Research - Pluripotent stem cell line expressing the AML1-ETO fusion protein established

Stem-Cell Transplantation - Allogeneic hematopoietic stem cell transplant for lymphoma should be selective

Stem-Cell Transplantation - Predictors of outcome identified in patients with metastatic rhabdomyosarcoma

Sun Protection - Tsunami Sun tearless sunscreen launched

Survival and Mortality - Older breast cancer patients in Canada benefit from early detection

Thyroid Cancer - Women with thyroid carcinoma at higher risk for second primary cancer

Tissue Engineering - Cartilage tissue regenerated by serum-free cultured chrondrocyte implantation

Tobacco Lawsuit - Judge orders tobacco company to hand over memo

Tobacco Use - Maternal smoking may play etiologic role in testicular cancer

Transfection - TIMP-2 gene transfer halts H-ras-induced breast endothelial cell invasion

Tumor Development - Neuroblastomas exposed to hypoxia undergo genetic shifts

Tumor Suppression - Adenoviruses bearing gfp-zeocin fusion cassettes select p53-deficient cells

Tumor Suppression - p16 Plasmids control telomerase activity in human gliomas

Tumorigenesis - Acquired periostin expression promotes breast cancer angiogenesis

Urology - The benefits of radical prostatectomy extend beyond cancer control

Vaccine Adjuvant - Cell death induced by vaccine adjuvants containing surfactants

Vaccine Development - Tumor necrosis factor autovaccination eliminates melanoma metastasis

Vector Development - Bone cancer cells respond to HSV thymidine kinase-ganciclovir gene therapy

Viral Disease - Biotech company testing possible antidote for bioterrorism viruses

West Nile Virus - West Nile virus-associated encephalitis seen in immunocompromised patients