Cancer Weekly

Acute myeloid leukemia - Fusion proteins overcome the hurdle of leukemia cell chemoresistance

Cancer Prognosis - Calcitonin gene hypermethylation marks the progress of leukemia

Chemotherapy - Oral RDP58 permits CPT-11 dose escalation and relieves gastric tract toxicity

Diagnostics - Human urine contains colorectal cancer detection markers

Fibrinolysis - Plasma D-dimer identifies lymph node metastasis in breast cancer patients

Acute Lymphoblastic Leukemia - Family having hematopoietic cancers poses slight risk of offspring getting ALL

Age-Related Macular Degeneration - SnET2 NDA accepted by FDA with priority review designation

Angiographic Imaging - Study initiated for ferumoxytol under company's agreements with NCI

Angiology - Platelet-derived growth factor stimulates pericyte recruitment to tumors

Awards - Doctor named young investigator of the year by gene therapy society

Awards - Memphis doctor wins cancer research award

B-Cell Lymphoma - c-FLIP mediates resistance of HRS cells to death receptor-induced apoptosis

Bile Duct Carcinoma - Retrograde portography shows important anatomy of the right caudate

Biotechnology - Four pH-dependent formation constants for free PSA elucidated

Blood Vessel - Company announces new intravenous gene-delivery method

Brain Tumors - Diagnosis and treatment of brain tumors in children has improved

Brain Tumors - Microdissection-based genotyping aids reactive gliosis vs. glioma diagnosis

Breast Cancer - Application filed for European marketing approval of RSR13 (efaproxiral)

Breast Cancer - Blood test detects genetic changes in progressive disease

Breast Cancer - Breast screening program in Australia detects more ductal carcinomas in situ

Breast Cancer - Combined mammography/MRI solution supports early detection of breast cancer

Breast Cancer - Complete nodal staging is beginning in men with breast cancer

Breast Cancer - ErbB3 is necessary for breast cancer proliferation

Breast Cancer - Follow-up data presented on autologous hemoderivative vaccine

Breast Cancer - Green tea may not decrease the risk of developing breast cancer

Breast Cancer - High mastectomy rates due to patients' choices, study finds

Breast Cancer - Increased access to high-quality mammography needed to reduce cancer deaths

Breast Cancer - MRI better than mammography for determining number, size of tumors

Breast Cancer - Nanoparticle form of paclitaxel is active in patients who failed taxane therapy

Breast Cancer - RARbeta P2 promoter methylation in RPFNA is biomarker for cancer risk

Breast Cancer - Researchers develop better understanding of tamoxifen resistance

Breast Cancer - Study casts doubt on Gail Model for predicting risk in African American women

Breast Cancer - Survivin, Bcl-2, p53 and bax expression increased in breast carcinoma

Breast Cancer - Vaccine containing multiple antigens generates higher immune response

Breast Cancer - Women treated for breast malignancies receive poor postoperative education

Business Update - Company acquires rights to novel proteasome inhibitors and related technology

Cachexia - Lipid-mobilizing factor protects tumor cells from oxidative damage

Cancer - Free electronic greeting cards offer encouragement to cancer patients

Cancer Biomarker - Epidermal growth factor receptor and Cerb-B2 fail to predict tongue cancer

Cancer Death Rates - Study finds rising death rates from prostate cancer after 15 years

Cancer Epidemiology - Annual report finds cancer incidence and death rates on the decline

Cancer Epidemiology - Men with vitamin D receptor polymorphisms are at risk for prostate cancer

Cancer Genomics and Genetics - Role of hMLH1 and HPP1 in adenocarcinomas determined

Cancer Prevention - Warfarin does not prevent bladder cancer formation

Cancer Risk - Cancer cause still a mystery in Vermont town

Cancer Risk - Illinois holding international conference on PCBs

Cancer Risk Factor - Familial tooth agenesis signals the risk for colorectal cancer

Cancer Risk Factor - Genetic shifts emerge during hepatitis C virus-linked carcinogenesis

Cancer Screening - U.S. National Cancer Institute in vitro drug screening has expanded

Cancer Suppression - Disrupted STAT3 signaling opens the door to tumor cell invasion

Cancer Surgery - Tumor cells can be removed from blood salvaged during cancer surgery

Cancer Therapy - ADVEXIN and INGN 241 featured at international scientific conference

Cancer Therapy - Alternating electric fields have potent antitumor activity

Cancer Therapy - Biomarker predicts response of colon cancer patients to chemotherapy regimen

Cancer Therapy - CMS and NCI collaborate to bring new drugs, better treatment to cancer patients

Cancer Therapy - Celecoxib is a potent chemopreventive agent

Cancer Therapy - Ceplene 36-month malignant melanoma survival data published

Cancer Therapy - Clinical safety, efficacy data of Advexin featured at scientific meeting

Cancer Therapy - Companies end Genasense expanded-access program in melanoma

Cancer Therapy - Drug treatment first big improvement in brain cancer in decades

Cancer Therapy - Endothelial cell-specific human antibodies might retard tumor growth

Cancer Therapy - Gene therapy tested to protect bone marrow during chemotherapy

Cancer Therapy - Hsp90 inhibitors enhance complement-induced tumor cell lysis

Cancer Therapy - Liver cancer expert presents new data on SIR-Spheres

Cancer Therapy - Loco-regional interferon after tumor irradiation regresses metastatic melanoma

Cancer Therapy - M2BP-derived CTL epitopes with possible use in cancer immunotherapy identified

Cancer Therapy - Medical product manufacturer to support CME program on RFA for cancerous tumors

Cancer Therapy - Near-infrared labeled endostatin localizes at tumors in animal models

Cancer Therapy - PTK/ZK completes enrollment for phase III metastatic colorectal cancer trial

Cancer Therapy - Patients' genes may influence how they experience fatigue and quality of life

Cancer Therapy - Phase I trial for anticancer compound Xl647 initiated

Cancer Therapy - Preclinical drug studies in rodents can predict phase I starting dose

Cancer Therapy - Researchers show potential of fighting angiogenesis

Cancer Therapy - Some drugs effective in rodent tumor models fail to perform clinically

Cancer Therapy - When combining new oral agents with standard chemotherapy, timing may be crucial

Cancer Threat - Study focusing on cancer link to creek in north Memphis

Cancer Treatment - Gene activity may change as breast cancer progresses

Cancer Treatment - Genetic differences explain severity of chemotherapy side effects

Cancer Treatment - Study shows virus can indicate cancer's aggressiveness

Cancer Vaccine - Antitumor immunity determined by the tumor not vaccine

Cancer Vaccine - B7-2 expression elicits anti-tumor immunity in B-cell lymphoma

Cancer vaccine - Cross-talk between dendritic and NK cells examined

Carcinogenesis - DNA methylation of integrin alpha 4 gene supports gastric cancer formation

Carcinoma - Bcl-2 expression decreases in endometrial carcinomas

Cell Biology - Researchers discover new way to identify cell growth

Cervical Cancer - Genital HPV infections very low in northern Greece

Cervical Cancer - Human papilloma virus testing should precede cervical biopsy

Cervical Cancer - SOC1 inhibits HPV-E7-mediated transformation via degradation of E7 protein

Cervical Cancer - Women having children by multiple partners have increased cancer risk

Collaborations - Agreement signed for development of phase I HDAC inhibitor for cancer

Collaborations - Biotech firms conclude agreement regarding manufacturing of cancer drug

Collaborations - Iconix announces chemogenomics collaborative relationship

Colon Cancer - Eloxatin study demonstrates benefit over standard colon cancer therapy

Colon Cancer - Red meat ingestion is likely responsible for increased colon cancer in Japan

Colon Cancer - States awarded grant for colorectal cancer prevention educational program

Colorectal Cancer - Alternative genetic pathway to human colorectal cancer found

Colorectal Cancer - Assessment of lymph nodes in colorectal cancer specimens needs improvement

Colorectal Cancer - Avastin study shows extended survival in metastatic colorectal cancer patients

Colorectal Cancer - Cytochrome C depletion intensifies the immunogenicity of colon cancer cells

Complementary and Alternative Medicine - Many cancer patients turn to complementary therapies for healing

DNA Damage - Attenuated p53 response in preneoplastic lesions growth advantage under stress

DNA Research - XPC protein plays key role in cell cycle regulation during cisplatin treatment

Diagnostic Imaging - Multishot and single-shot fast spin echo sequences enhance tumor imaging

Diagnostics - A new quantitation assay details human papillomavirus load

Diagnostics - FDA approves Second Look 200 for breast-cancer detection

Diagnostics - FDA approves expanded labeling claims for SurePath Liquid-Based Pap Test

Diagnostics - Intraoperative ultrasonography use is increasing in urologic oncology

Diagnostics - Pin1 may link signal transduction to cancer and Alzheimer disease

Drug Delivery - Degarelix-loaded PLGA microparticles may enhance prostate cancer treatment

Drug Delivery - Endothelial proteins accessible to drugs injected intravenously

Drug Delivery - Percutaneous intra-arterial catheter implantations transport liver cancer drugs

Drug Development - Bispecific antibody shows promise as lymphoma therapy

Drug Development - Multicellular tumor spheroids model HSVtk/ganciclovir systems in vitro

Drug Development - Puupehenone and associated compounds are angiogenesis inhibitors

Drug Development - Recombinant anti-MUC1 scFv has improved stability

Drug Resistance - Bleomycin resistance stems from faulty transport mechanisms

Drug Resistance - Downregulated Bcl-2 or xIAP enhances the efficacy of breast cancer chemotherapy

Drug Resistance - Wild-type p53 polymorphisms anchor chemotherapeutic response

End-stage Liver Disease - De novo liver cancer in liver transplant candidates warrants list advancement

Endocrinology - Vitamin D-mediated prostate cancer inhibition requires androgen signals

Endometrial Cancer - Case report shows adenocarcinoma producing only free beta subunit of hCG

Endometrial Cancer - Clinicopathologic differences identified between EC and benign disease

Environmental Toxins - Groups tout study showing lives lost to power plant pollution

Enzymology - Histone deacetylation is involved in ras-induced suppression of RECK

Ethics - Age, race and sex disparity found in cancer research trial participation

Eye Cancer - New laboratory model can be used to test new treatments for pediatric eye cancer

Facilities - MaineGeneral board to build cancer center

Fertility - Autotransplantation of ovarian tissue recommended for trials only

Fertility - Oocyte cryopreservation gives cancer patients hope

Finance - Cancer immunotherapies company announces closing of public offering

Finance - Cancer vaccine maker reports $1M net loss

Fungal Infection - Voriconazole may prevent fungal relapse during at-risk periods of leukemia

Gastric Carcinoma - Histologically diverse lymph node lesions signal poor outcome in gastric cancer

Gastroenterology - Aurora-2 is a potential target for the treatment of pancreatic cancer

Gastroenterology - Clofazimine in lipiodol diminishes liver tumors in rodent cancer models

Gene Transfer - NK4 transfection generates several modes of antitumor activity

Genetic Engineering - Administration route shapes the effects of IL-12-expressing dendritic cells

Genetic Mutation - Germline mutations in Chernobyl cleanup workers' offspring are modest

Genomics - Pharmacogenomic profiling of PI3K/PTEN-AKT-mTOR pathway in tumors elucidated

Geriatrics - Plasmid-based hormone therapy could improve disease or age-induced wasting