HIV/AIDS Treatment
Vif-resistant mutant APOBEC3G may provide gene therapy approach to HIV infection
Published in Cancer Weekly, June 29th, 2004
"HIV-1 and other retroviruses occasionally undergo hypermutation, characterized by a high rate of G-to-A substitution. Recently, the human apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3G (APOBEC3G), first identified as CEM15, was shown to be packaged into retroviral virions and to deaminate deoxycytidine to deoxyuridine in newly synthesized viral minus-strand DNA, thereby inducing G-to-A hypermutation," researchers at the US National Cancer Institute report.
"This innate mechanism of resistance to retroviral infection is counteracted by the...
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Source: Cancer Weekly (2004-06-29)
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