Mutagenesis

Telomere length is maintained during early tumorigenesis

Published in Cancer Weekly, June 29th, 2004

Telomere length is maintained during early tumorigenesis.

According to a study from England, "human telomeres are essential for genome stability and are composed of long simple tandem repeat arrays (STRs), comprising the consensus TTAGGG repeat interspersed, at the proximal end, with sequence-variant repeats. While the dynamics of telomere attrition through incomplete replication has been studied extensively, the effects on telomeres of error-prone DNA repair processes, known to affect other STRs, are poorly understood. We have compared the TTAGGG and sequence-variant interspersion patterns in the proximal 720 bp of telomeres in colon cancer and normal DNA...

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Source: Cancer Weekly (2004-06-29)

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