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Neurotoxicity

The advent of ifosfamide-related encephalopathy is unpredictable

Published in Cancer Weekly, June 29th, 2004

The advent of ifosfamide-related encephalopathy is unpredictable.

"This retrospective trial was performed to determine risk factors, incidence and severity of ifosfamide-induced encephalopathy in correlation with patient and treatment characteristics. Patients receiving ifosfamide were included consecutively with no restrictions concerning disease, prior chemotherapy or disease stage. Incidence and severity of encephalopathy were graduated according to common toxicity criteria," researchers in Germany report.

"Between July 2001 and July 2002, 60 patients (32 male, 28 female, median age 47.5 years) were included; 26.6% of the patients (n=16) developed...

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