Acute myeloid leukemia
Fusion proteins overcome the hurdle of leukemia cell chemoresistance
Published in Cancer Weekly, June 29th, 2004
According to recent research from the United States, "chemoresistance is a common cause of treatment failure in patients with acute myeloid leukemia (AML). We generated a diphtheria toxin (DT) fusion protein composed of the catalytic and translocation domains of DT (DT388) fused to interleukin-3 (IL-3). IL-3 receptors (IL-3R) are overexpressed on blasts from many AML patients."
"DT388IL-3 showed cytotoxicity to leukemic blasts in vitro and in vivo and minimal damage to normal tissues in nonhuman primate models. However, only a fraction of patient leukemic samples were sensitive to...
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Source: Cancer Weekly (2004-06-29)
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