Published in Cancer Weekly, June 29th, 2004
"Using methylation-specific real-time PCR," researchers in Germany "determined the prevalence of aberrant methylation in the mismatch repair gene hMLH1 and in the recently described HPP1 gene among 50 esophageal, 50 cardiac and 50 gastric ADCs."
"Additionally, expression of hMLH1 protein was detected immunohistochemically and correlated with DNA MSI [microsatellite instability]," noted H. Geddert and coauthors at the University of Dusseldorf.
"Hypermethylation of hMLH1 was found in 14% of esophageal, 28% of cardiac and...
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