Cancer Genomics and Genetics

Role of hMLH1 and HPP1 in adenocarcinomas determined

Published in Cancer Weekly, June 29th, 2004

The roles of the hMLH1 and HPP1 genes in adenocarcinoma have been elucidated.

"Using methylation-specific real-time PCR," researchers in Germany "determined the prevalence of aberrant methylation in the mismatch repair gene hMLH1 and in the recently described HPP1 gene among 50 esophageal, 50 cardiac and 50 gastric ADCs."

"Additionally, expression of hMLH1 protein was detected immunohistochemically and correlated with DNA MSI [microsatellite instability]," noted H. Geddert and coauthors at the University of Dusseldorf.

"Hypermethylation of hMLH1 was found in 14% of esophageal, 28% of cardiac and...

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Source: Cancer Weekly (2004-06-29)

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