Published in Cancer Weekly, July 6th, 2004
According to recent research published in the journal Neuropharmacology, "the effects of anti-allergic agents on the hypersensitivity reactions to paclitaxel, an anti-cancer agent, were examined in rats. Intravenous injection of paclitaxel (15 mg/kg) caused a marked extravasation of plasma protein in lungs and a transient decrease in arterial partial oxygen pressure (PaO2 )." "
"The paclitaxel-induced protein extravasation was inhibited by low doses(0.1-1 mg/kg) of pemirolast or high doses (30-100 mg/kg) of cromoglycate. However, ketotifen was not effective....
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