Allergy Medicine

Pemirolast is a potent reliever of paclitaxel-induced allergic reactions

Published in Cancer Weekly, July 6th, 2004

Pemirolast is a potent reliever of paclitaxel-induced allergic reactions.

According to recent research published in the journal Neuropharmacology, "the effects of anti-allergic agents on the hypersensitivity reactions to paclitaxel, an anti-cancer agent, were examined in rats. Intravenous injection of paclitaxel (15 mg/kg) caused a marked extravasation of plasma protein in lungs and a transient decrease in arterial partial oxygen pressure (PaO₂ )." "

"The paclitaxel-induced protein extravasation was inhibited by low doses(0.1-1 mg/kg) of pemirolast or high doses (30-100 mg/kg) of cromoglycate. However, ketotifen was not effective....

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Source: Cancer Weekly (2004-07-06)

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