Hepatocellular Carcinoma

Mutant p53 expression linked to drug resistance in a hepatocellular carcinoma

Published in Cancer Weekly, July 13th, 2004

Study finds that the p53 mutant, R248Q, in a liver cancer cell line may enhance chemotherapy drug resistance.

"Chemoresistance is a major problem in the treatment of hepatocellular carcinoma. Certain p53 mutants may enhance drug resistance in cancer cell," scientists in People's Republic of China report.

"To determine whether two frequently occurring p53 mutants, R248Q and R273C, would increase the drug resistance of liver cancer cells, stable cell lines expressing these specific p53 mutants were established by transfecting the p53-null Hep3B cells with mutant p53 expression vectors, and then treating them with the anticancer drugs doxorubicin and...

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Source: Cancer Weekly (2004-07-13)

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