CNTO 95 blocks alpha(v) integrins to suppress tumors in mice

According to a study from the United States, "integrins of the alpha(v) family, such as alpha(v)beta(3) and alpha(v)beta(5), are implicated in tumor-induced angiogenesis; but their role in tumor growth has not been fully explored. CNTO 95 is a fully human antibody that recognizes the alpha(v) family of integrins and is likely to be less immunogenic in humans compared to chimeric or humanized antibodies."

"CNTO 95 bound to purified alpha(v)beta(3) and alpha(v)beta(5) with a K-d of approximately 200 pM and to alpha(v) integrin-expressing human cells with a K-d of 1-24 nM. In vitro, CNTO 95...

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