Multiple Myeloma
Methylation epigenetically regulates tumor-suppressing genes
Published in Cancer Weekly, July 20th, 2004
"The epigenetic control of gene transcription in cancer has been the theme of many recent studies and therapeutic approaches," oncologists in the United States explained. "Carcinogenesis is frequently associated with hypermethylation and consequent downregulation of genes that prevent cancer, e.g, those that control cell proliferation and apoptosis."
In their study, C. Pompeia and colleagues at the National Cancer Institute "used the demethylating drug zebularine to induce changes in DNA methylation, then examined patterns of gene expression using cDNA...
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Source: Cancer Weekly (2004-07-20)
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