Neuroprotection
Local neurotrophic factor expression rescues motoneurons in study animals
Published in Cancer Weekly, July 20th, 2004
According to recent research published in the journal Neurobiology of Disease, "approximately 2% of amyotrophic lateral sclerosis (ALS) cases are associated with mutations in the cytosolic Cu/Zn superoxide dismutase 1 (SOD1) gene. Transgenic SOD1 mice constitute useful models of ALS to screen therapeutical approaches. Glial cell line-derived neurotrophic factor (GDNF) holds promises for the treatment of motoneuron disease."
"In the present study, GDNF expression in motoneurons of SOD1(G93A) transgenic mice was assessed by facial nucleus or intraspinal injection of...
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Source: Cancer Weekly (2004-07-20)
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