Adverse Drug Effects

Non-protein bound iron may be responsible for chemotherapy-induced toxicity

Published in Cancer Weekly, July 20th, 2004

Non-protein bound iron may be responsible for chemotherapy-induced toxicity.

According to a study from the Netherlands, "non-protein bound iron (NPBI) is able to catalyze oxidative reactions, causing damage to vital structures. Adverse effects induced by cisplatin seem, in part, to be mediated by free radicals. In the present study, we have measured plasma NPBI, various other iron parameters, and antioxidants in 28 cancer patients undergoing cisplatin-based chemotherapy at various time points before and during chemotherapy."

"No NPBI was present prior to therapy, but within 1-4 days following the first administration of chemotherapy, mean NPBI rose...

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Source: Cancer Weekly (2004-07-20)

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