Mutagenesis
Metastatic lesions from head and neck cancers often lose chromosome Y
Published in Cancer Weekly, July 20th, 2004
According to a study from Poland, "the loss of chromosome Y has often been observed in human solid tumors. This chromosome aberration has been proposed as one of genetic changes predisposing men to squamous cell carcinoma of the head and neck (SCCHN)."
"In this study, using cytogenetic analysis and fluorescence in situ hybridization we analyzed: 16 cell lines derived from primary and recurrent SCCHN, a group of 22 samples derived from previously analyzed primary larynx tumors and their corresponding metastases, and a group of eight multiple primary tumors received from two...
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Source: Cancer Weekly (2004-07-20)
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