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Cancer Weekly

Susan Hasty, Publisher

Table of Contents . . . July 27th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Cancer Weekly | Other Publications

Breast Cancer - Quantitative ultrasound can help determine mammary tumor type

Cancer Therapy - DNA methylation shows promise for treating advanced prostate cancer

Cancer Therapy - IND application granted for cancer drug MN-029

Colorectal Cancer - A new transcriptional regulator derailed in carcinomas

Prostate Cancer - Location and function of TARP characterized

Acoustic Neuroma - Translabyrinthine microsurgery preserves facial nerve function

Acute Lymphoblastic Leukemia - High-dose melphalan-based autograft reported safe in ALL in first remission

Alternative Therapies - Spice phenolics inhibit human PMNL 5-lipoxygenase

Alternative Therapy - Heat increases antioxidant activity of extracts from citrus peels

Anal Cancer - Changing trends in sexual behavior may explain rising incidence of anal cancer

Anthrax - Research uncovers crystal structure for cell binding complex

Anti-Tobacco Campaign - Religious leaders launch anti-tobacco campaign

Awards - EPA recognizes commitment to developing environmentally responsible processes

Bioinformatics - A new model characterizes vascular collapse in solid tumors

Biomarker - Angiogenic factors have clinical relevance in patients with lymphoma

Bladder Cancer - Green tea extract, targeted therapy to be tested as cancer prevention agents

Bladder Cancer - Unexpected high rate of bladder cancer present in elderly male study patients

Brain Cancer - Caldesmon gene splice variants are different in the glioma vascular system

Breast Cancer - Alliance aims to increase access to partial breast irradiation

Breast Cancer - Chemoradioimmunotherapy may hold promise for advanced disease

Breast Cancer - FDA grants priority review for Femara as post-tamoxifen treatment

Breast Cancer - Fractal models help detect, classify microclassifications

Breast Cancer - Gene polymorphism may be risk factor for increased disease susceptibility

Breast Cancer - HER-2/neu independent prognostic factor for survival in metastatic breast cancer

Breast Cancer - Interleukin-12 intervenes in the growth of murine mammary tumors

Breast Cancer - Lack of diagnostic follow-up may reduce mammography screening effectiveness

Breast Cancer - Large, long-term study looks at dietary risk factors in postmenopausal women

Breast Cancer - Mastascope introduced for early detection of breast abnormalities

Breast Cancer - New 2D segmentation method applied to CAD in mammography

Breast Cancer - Novel steroid sulfatase inhibitor inhibits breast tumor growth in rat model

Breast Cancer - P27kip1 downregulation linked to trastuzumab resistance

Breast Cancer - Pessimism puts breast cancer patients at greater risk for anxiety, depression

Breast Cancer - Premature menopause, sexual functioning important concerns of younger patients

Breast Cancer - Risk factors explain increased susceptibility of educated Scandanavian women

Breast Cancer - Routine mammographic breast density measurements may help determine risk

Breast Cancer - Stress from caregiving isn't a risk factor

Breast Cancer - Study characterizes carcinoma arising from pre-existing PLH and CHH lesions

Breast Cancer - Sunesis begins clinical study of anticancer drug

Breast Cancer - Technology could enhance biopsy accuracy

Breast Cancer - sHER-2/neu status predictive indicator for benefit from paclitaxel chemotherapy

Bronchoalveolar Carcinoma - Phase II trial of GVAX lung cancer vaccine begins

Business & Finance - Biotechnology company announces significant operational review is underway

Business & Finance - Technology expands to independent imaging centers

Business Update - Company focuses on therapeutic vaccines, slashes workforce to cut expenses

Business Update - Stock trading program implemented at biotech company

Cancer - Biopharmaceutical company acquires full rights to Aloprim

Cancer - Environmental exposures affect the carcinogenicity of heterocyclic amines

Cancer - MRP1 and GlcCer are over expressed and enriched in colon cancer cells

Cancer - Palonosetron HCl injection poster presentations made at MASCC symposium

Cancer - Zerumbone suppresses skin tumor initiation and promotion stages in ICR mice

Cancer Awareness - Secretary of State offers stern advice on prostate cancer

Cancer Cluster - Arkansas researcher to study Nevada cancer cluster

Cancer Diagnosis - Response submitted to FDA on approvable letter for Combidex

Cancer Diagnostics - CellSearch Epithelial Cell Control Kit receives 510(k) clearance from FDA

Cancer Diagnostics - Sample fixation procedure does not affect MIB-1 immunostaining

Cancer Genetics - Communication patterns in families with breast/ovarian cancer history described

Cancer Genomics and Genetics - Genes expressed in head and neck cancer identified

Cancer Prevention - Allina Hospitals & Clinics go tobacco free

Cancer Prevention - Milk, calcium again linked to colon cancer protection

Cancer Progression - Crosstalk between angiogenesis and lymphangiogenesis provokes tumor progression

Cancer Risk - Rapid rise in PSA level sign of aggressive prostate cancer

Cancer Survivor - Cancer survivor turns her sights to education

Cancer Therapy - Anti-cancer activities of INGN 241 reviewed in medical journal

Cancer Therapy - Anticancer agent built from anti-inflammation drug

Cancer Therapy - Biotech company closes license agreement on extension of HSV technology

Cancer Therapy - Combination trial with Telcyta for non-small cell lung cancer initiated

Cancer Therapy - IND application filed for anticancer compound XL999

Cancer Therapy - In situ tumor ablation creates antigen source for antitumor immunity induction

Cancer Therapy - Kinase inhibitor picked for clinical development in oncology, edema indications

Cancer Therapy - Oncology company enters agreement for access to DNA repair research

Cancer Therapy - Patients anticipate high number of side effects to cancer treatment

Cancer Therapy - Pharmaceutical company announces patent grants for vascular targeting agents

Cancer Therapy - Phase I trial of PXD101 begins in patients with hematologic cancer

Cancer Therapy - Structure shows how one human protein reduces the potency of chemotherapy

Cancer Treatment - Nebraska Medical Center rates 36th in nation for cancer care

Cancer Treatment - Rare cancer overpowers a brave young girl

Cancer Treatment - UF surgeons remove cancer from liver outside the body

Cancer Treatment - University of Nebraska Medical Center gets help with child cancer

Cancer Vaccine - Immunofluorescence test to detect varicella-zoster IgG developed

Cancer Vaccine - Potent vaccine-induced anti-tumor T cell response characterized

Cancer Vaccine - Poxvirus vaccine plus celecoxib elicits antitumor immunity

Cancer Vaccine - SSX-2-derived epitope recognized by CD4+ T cells along with HLA-DR

Cancer Vaccine - Tumor cell-based vaccines are potent activators of CD4+ T lymphocytes

Candidiasis -  Candida in concentrated oral rinse cultures detected by real-time PCR

Cervical Cancer - HPV vaccine targeting women age 24-45 is under study

Cervical Cancer - Imaging technology differentiates lesions, provides tumor biology insight

Cervical Cancer - Keratins 8, 10, 13, and 17 are useful diagnostic tumor markers

Cervical Cancer - Mechanism of HPV oncogene regulation of tumorigenesis described

Cervical Cancer - P73 expression associated with cellular radiosensitivity after radiotherapy

Chemokines - Upregulated MIF increases angiogenic factor levels in neuroblastoma

Childhood Adrenocortical Tumors - U.S. researchers report on childhood adrenocortical tumors

Clinical Genetics - Genetic profiling has advanced our knowledge of non-small cell lung cancer

Clinical Trials - NCI selects research organization to support preclinical studies

Coagulation Therapy - Novel tissue factor pathway inhibitor peptide obstructs tumor growth

Collaborations - Biopharma signs agreement to manufacture Coley's Toxin cancer vaccine

Collaborations - Cancer therapeutics alliance formed

Collaborations - Companies agree to develop and commercialize VX-680 for cancer

Collaborations - Europroteome enters molecular profiling collaboration

Collaborations - Geron announces agreement to conclude collaboration

Collaborations - Leukemia groups to expand patient services through Canada

Colorectal Cancer - Total vitamin D but not dietary alone prevents cancer

Complementary & Alternative Medicine - Black cohosh extract doesn't induce endometrial tumor growth in rat study

Coronary Artery Bypass Graft Surgery - KTX 0101 studied for prevention of cognitive impairment in CABG surgery patients

Coronary Heart Disease - Prostate cancer and coronary heart disease share some risk factors

Cutaneous T-Cell Lymphoma - Targretin cutaneous T-cell lymphoma therapy reimbursed by Medicare

Cytomegalovirus - Graft outcome with CMV prophylaxis depends on donor/recipient antibody status

DNA Vaccine - Heat-shock protein as dendritic cell target enhances vaccine potency

Dermatology - Melanocytes express 3G5 surface antigen

Diagnostics - Dynamic contrast-enhanced MRI shows how angiostatic drugs erase angiogenesis

Diet & Nutrition - Healthy eating and living can indeed reduce women's risk of getting cancer

Diet and Nutrition - Plant estrogens in soy don't appear to increase breast or uterine cancer risk

Drug Development - HKI-272 shows promise as breast cancer therapy

Drug Development - Liposomal formulation of OSI-7904 has improved efficacy

Drug Development - The novel Escherichia coli YeiK gene product is a gene therapy candidate

Drug Resistance - Bcl-2 antisense agent G3139 invokes a response to refractory multiple myeloma

Drug Resistance - Paclitaxel resistance in ovarian cancer patients likely multifactorial

Endometrial Cancer - Animal research suggests that stress may increase risk of uterine cancer

Endometrial Cancer - CYP17 and CYP19 genetic polymorphisms may play role in carcinogenesis

Endometrial Cancer - Correlation found among endocrine receptors in tumors and eutopic endometria

Endometriosis - Endometrial cells can originate from donor-derived bone marrow cells

Environmental Toxicology - Dothistroma needle blight of pines produces dothistromin, a carcinogenic toxin

Enzymology - Heparanase has a direct effect on angiogenesis

Finance - Biomarker company forecasts second-quarter revenue drop

Finance - Device company files past-due financial reports

Finance - Diagnostics company added to Russell 3000 Index, Merrill Lynch Nanotech Index

Finance - Diagnostics developer added to Russell 3000 Index, Merrill Lynch Nanotech Index

Finance - Paxis parent adopts stock repurchase plan

Ganglioglioma - Cerebral blood volume test can help determine glioma type

Gastroenterology - Neuropilin-1 is an angiogenesis induction factor in human colon cancers

Genetic Risk Factor - c-MPL gene mutations generate familial essential thrombocytosis

Genetics - Harvard patent on genetically altered mouse upheld

Genomics and Genetics - ChIP microarrays can identify genes silenced in cancer

Glioblastoma - Data published on telomerase inhibitor GRN163 in rodent models of brain tumors

Gynecology - Arias-Stella reaction of the endocervix characterized

Health Risk - Health officials say consult UV index to prevent sunburn

Hematological Oncology - Imatinib therapy reverses bone marrow angiogenesis in leukemia patients

Human Papillomavirus - Study suggests first molecular target to halt spread of HPV

Human Papillomavirus Vaccine - Dendritic cells expressing HPV16-E7 inhibited by co-expression of IL12

Human Papillomavirus Vaccine - Hypervariable epitopes induce immune responses against papillomaviruses

Human Papillomavirus Vaccine - Presentation system improves cellular immunity against papillomavirus

Imaging - Emory announces first clinical use in the U.S. of new On-board Imager

Immune Therapy - Rhabdomyosarcomas potential target of MAGE-specific immunotherapies

Immunology - Anti-CD30-scFv-Fc-IL-2 fusion induces resting NK cells to lyse lymphoma cells

Immunology - Bcl-2 expression is strongest prognostic factor of survival in B-cell lymphomas

Immunology - CD40 ligand gene therapy halts Th2-mediated tumor escape

Immunology - Impaired IFN-alpha-production of DCs may contribute to ATL immunodeficiency

Immunosuppression - Rapamycin targets tumors but protects allografts from rejection

Legal Issues - Securities class action suit filed against Genta Incorporated

Leukemia - Complex chromosomes not always associated with rapid disease evolution in MDS

Leukemia - Researchers report on HOX expression's association with biologic subset of AML

Liver Metastases - Researchers report on liver metastases resection procedures

Longevity - Croatian skeletons reveal changing status of cancer in Europe over time

Lung Cancer - Biotechnology company announces Tarceva was accepted into FDA's Pilot 1 Program

Lung Cancer - Brochure helps patients better understand radiation therapy

Lung Cancer - Depression coping associated with shorter survival in lung cancer study

Lung Cancer - INGN 241 with radiation inhibits tumor growth in animal model lung cancer study

Lung Cancer - New data suggest FUS1 therapy may play role in preventing onset of lung cancer

Lung Cancer - Observations from European clinical trials of TC-99M Hynic-Annexin released

Medical Imaging - Chromatography technique can be applied to anti-cancer drugs

Medical Technology - FDA clearances granted for software to review multi-detector CT chest exams

Melanoma - Phase 2 clinical trial studying anti-tumor activity of Talabostat initiated

Mergers & Acquisitions - AltaGen Biosciences acquired by biological products company

Mergers & Acquisitions - Cephalon reports agreement in principle with FTC staff on proposed merger

Mergers and Acquisitions - Brachytherapy seed developer announces merger

Mergers and Acquisitions - Medical device manufacturer extends merger discussions

Mergers and Acquisitions - Oncology drug development company to merge with biotechnology company

Metastasis - Hypoxia-inducible factors enhance cancer cell dissemination mechanisms

Metastasis - Metacept-1 and oxamflatin hinder cancer cell invasion and dissemination

Multiple Myeloma - Preclinical data on huN901-DM1 in multiple myeloma published in cancer journal

Myeloma - VEGF receptor inhibitor GW654652 discourages multiple myeloma metastasis

Nausea - FDA approval granted for Promethazine Hydrochloride tablets

Neuroblastoma - Amplifications in chromosome arm 1p identified

Omega-3 Fatty Acids - Health-promoting Omega-3 fatty acids may be produced in bioengineered plants

Oncogenes - Cancer gene MYC emerging as key research target

Oncology - Oncology drugs dominate pharmaceutical pipelines

Oncology - Proteo-genomics system identifies malignant antibody targets

Oncovirus - Heme oxygenase-1 is a therapeutic target for the treatment of Kaposi sarcoma

Ovarian Cancer - Dose-intense triplet chemotherapy with PBPC support investigated

Ovarian Cancer - Molecules that promote OC dissemination id'd by Drosophila genetic analysis

Ovarian Cancer - NF kappa B inhibition increases cisplatin efficacy in ovarian cancer models

Ovarian Cancer - Proposed disease model is based on morphological and molecular genetic analysis

Pancreatic Cancer - Ad/TRAIL-F/RGD may be potent therapeutic agent for pancreatic cancer

Pancreatic Cancer - Initial clinical data from GVAX pancreatic cancer vaccine program

Pancreatic Cancer - Positive CoFactor results reported in pancreatic tumor model

Pediatrics - PHOX2B gene mutations are not associated with sudden infant death syndrome

Peripheral Blood - Melanoma peptide cocktail generates T cells against malignant melanoma

Personnel - Biopharmaceutical company appoints vice president, director France

Personnel - Biotech company appoints Sara A. Courtneidge to advisory board

Personnel - CRO announces further expansion of its West Coast operations

Personnel - Gerhard Baumgartner joins Chemophase maker's scientific advisory board

Personnel - Synta appoints three physicians to oncology advisory board

Polio - Vaccine scandal revives cancer fears

Product Licensing - Spire receives catheter license payment from Bard

Prostate Cancer - Antigen may play role in treatment decisions

Prostate Cancer - Lifestyle changes can help prevent prostate cancer

Prostate Cancer - NDA submitted for Xinlay in the U.S.

Prostate Cancer - Novel candidate oncogene identified

Prostate Cancer - Study examines at-risk men's decision-making on prostate cancer screening

Pulmonary Medicine - Nucleotide insertions reverse the cystic fibrosis phenotype in tissue cultures

Radiation Oncology - Emory pioneers robotic system for precision radiation treatments

Radiation Therapy - Case report highlights risk of chemotherapy-induced radiation recall colitis

Restructuring - Drug-discovery company to focus resources on expanding clinical pipeline

Retrovirus Infection - HTLV-I infection may modify DPB pathogenesis via T cell activation

Smoking Ban - Ireland health minister vows to crush pub's rebellion against smoking ban

Smoking Ban - Statewide indoor smoking ban begins in Massachusetts

Solid Tumors - Phase I trial of CF101 with chemotherapy initiated

Stem Cell Research - Double labeling method measures cell turnover rates in colon

Stem Cell Transplantation - Deletion of chromosome band 13q14 prognostic factor in multiple myeloma with SCT

Stem-Cell Research - AML1-ETO in hematopoietic stem cells preferentially enhances their maintenance

Stem-Cell Research - Jagged1-induced Notch signaling drives multiple myeloma cell proliferation

Stem-Cell Research - L3MBTL implications for pathogenesis of myeloid malignancy 20q deletions

Stem-Cell Research - SCL required for normal function of short-term repopulating hematopoietic SCs

Stem-Cell Research - Type I HBEC immortalization may be early step in breast cancer subset initiation

Stem-Cell Transplantation - Acute gastrointestinal GVHD diagnosed frequently after allogeneic HCT

Stem-Cell Transplantation - CSP/MMF in URD HSCT patients acceptable toxicity but high rates of GVHD

Stem-Cell Transplantation - Chimeric CD19 Ab is option in post-transplant minimal residual B-lineage ALL

Stem-Cell Transplantation - EBV viral load monitoring best used to enable prompt treatment of PTLDs

Stem-Cell Transplantation - HSC source should be considered based on data for individual ethnic populations

Stem-Cell Transplantation - Severe cGVHD characterized by high CD4+ cells relative to central memory cells

Therapeutics - Sloan-Kettering to research positive health impacts of flower pollen extract

Tumor Suppression - Loss of LGI1 gene activity encourages glioma invasion

Vascular Diseases - Educational level is inversely associated with mortality

Vascular Targeting - FDA clears IND for Exherin

Vector Development - Human serum albumin nanoparticles deliver antisense nucleotides to tumor cells

Vector Development - Scalable production platform for oncolytic adenoviral vectors developed

Virology - Human herpesvirus type 8 and HCV coinfections show differential transmission

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