Susan Hasty, Publisher
Table of Contents . . . July 27th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Cancer Weekly | Other Publications
Breast Cancer - Quantitative ultrasound can help determine mammary tumor type
Cancer Therapy - DNA methylation shows promise for treating advanced prostate cancer
Cancer Therapy - IND application granted for cancer drug MN-029
Colorectal Cancer - A new transcriptional regulator derailed in carcinomas
Prostate Cancer - Location and function of TARP characterized
Acoustic Neuroma - Translabyrinthine microsurgery preserves facial nerve function
Acute Lymphoblastic Leukemia - High-dose melphalan-based autograft reported safe in ALL in first remission
Alternative Therapies - Spice phenolics inhibit human PMNL 5-lipoxygenase
Alternative Therapy - Heat increases antioxidant activity of extracts from citrus peels
Anal Cancer - Changing trends in sexual behavior may explain rising incidence of anal cancer
Anthrax - Research uncovers crystal structure for cell binding complex
Anti-Tobacco Campaign - Religious leaders launch anti-tobacco campaign
Awards - EPA recognizes commitment to developing environmentally responsible processes
Bioinformatics - A new model characterizes vascular collapse in solid tumors
Biomarker - Angiogenic factors have clinical relevance in patients with lymphoma
Bladder Cancer - Green tea extract, targeted therapy to be tested as cancer prevention agents
Bladder Cancer - Unexpected high rate of bladder cancer present in elderly male study patients
Brain Cancer - Caldesmon gene splice variants are different in the glioma vascular system
Breast Cancer - Alliance aims to increase access to partial breast irradiation
Breast Cancer - Chemoradioimmunotherapy may hold promise for advanced disease
Breast Cancer - FDA grants priority review for Femara as post-tamoxifen treatment
Breast Cancer - Fractal models help detect, classify microclassifications
Breast Cancer - Gene polymorphism may be risk factor for increased disease susceptibility
Breast Cancer - HER-2/neu independent prognostic factor for survival in metastatic breast cancer
Breast Cancer - Interleukin-12 intervenes in the growth of murine mammary tumors
Breast Cancer - Lack of diagnostic follow-up may reduce mammography screening effectiveness
Breast Cancer - Large, long-term study looks at dietary risk factors in postmenopausal women
Breast Cancer - Mastascope introduced for early detection of breast abnormalities
Breast Cancer - New 2D segmentation method applied to CAD in mammography
Breast Cancer - Novel steroid sulfatase inhibitor inhibits breast tumor growth in rat model
Breast Cancer - P27kip1 downregulation linked to trastuzumab resistance
Breast Cancer - Pessimism puts breast cancer patients at greater risk for anxiety, depression
Breast Cancer - Premature menopause, sexual functioning important concerns of younger patients
Breast Cancer - Risk factors explain increased susceptibility of educated Scandanavian women
Breast Cancer - Routine mammographic breast density measurements may help determine risk
Breast Cancer - Stress from caregiving isn't a risk factor
Breast Cancer - Study characterizes carcinoma arising from pre-existing PLH and CHH lesions
Breast Cancer - Sunesis begins clinical study of anticancer drug
Breast Cancer - Technology could enhance biopsy accuracy
Breast Cancer - sHER-2/neu status predictive indicator for benefit from paclitaxel chemotherapy
Bronchoalveolar Carcinoma - Phase II trial of GVAX lung cancer vaccine begins
Business & Finance - Biotechnology company announces significant operational review is underway
Business & Finance - Technology expands to independent imaging centers
Business Update - Company focuses on therapeutic vaccines, slashes workforce to cut expenses
Business Update - Stock trading program implemented at biotech company
Cancer - Biopharmaceutical company acquires full rights to Aloprim
Cancer - Environmental exposures affect the carcinogenicity of heterocyclic amines
Cancer - MRP1 and GlcCer are over expressed and enriched in colon cancer cells
Cancer - Palonosetron HCl injection poster presentations made at MASCC symposium
Cancer - Zerumbone suppresses skin tumor initiation and promotion stages in ICR mice
Cancer Awareness - Secretary of State offers stern advice on prostate cancer
Cancer Cluster - Arkansas researcher to study Nevada cancer cluster
Cancer Diagnosis - Response submitted to FDA on approvable letter for Combidex
Cancer Diagnostics - CellSearch Epithelial Cell Control Kit receives 510(k) clearance from FDA
Cancer Diagnostics - Sample fixation procedure does not affect MIB-1 immunostaining
Cancer Genetics - Communication patterns in families with breast/ovarian cancer history described
Cancer Genomics and Genetics - Genes expressed in head and neck cancer identified
Cancer Prevention - Allina Hospitals & Clinics go tobacco free
Cancer Prevention - Milk, calcium again linked to colon cancer protection
Cancer Progression - Crosstalk between angiogenesis and lymphangiogenesis provokes tumor progression
Cancer Risk - Rapid rise in PSA level sign of aggressive prostate cancer
Cancer Survivor - Cancer survivor turns her sights to education
Cancer Therapy - Anti-cancer activities of INGN 241 reviewed in medical journal
Cancer Therapy - Anticancer agent built from anti-inflammation drug
Cancer Therapy - Biotech company closes license agreement on extension of HSV technology
Cancer Therapy - Combination trial with Telcyta for non-small cell lung cancer initiated
Cancer Therapy - IND application filed for anticancer compound XL999
Cancer Therapy - In situ tumor ablation creates antigen source for antitumor immunity induction
Cancer Therapy - Kinase inhibitor picked for clinical development in oncology, edema indications
Cancer Therapy - Oncology company enters agreement for access to DNA repair research
Cancer Therapy - Patients anticipate high number of side effects to cancer treatment
Cancer Therapy - Pharmaceutical company announces patent grants for vascular targeting agents
Cancer Therapy - Phase I trial of PXD101 begins in patients with hematologic cancer
Cancer Therapy - Structure shows how one human protein reduces the potency of chemotherapy
Cancer Treatment - Nebraska Medical Center rates 36th in nation for cancer care
Cancer Treatment - Rare cancer overpowers a brave young girl
Cancer Treatment - UF surgeons remove cancer from liver outside the body
Cancer Treatment - University of Nebraska Medical Center gets help with child cancer
Cancer Vaccine - Immunofluorescence test to detect varicella-zoster IgG developed
Cancer Vaccine - Potent vaccine-induced anti-tumor T cell response characterized
Cancer Vaccine - Poxvirus vaccine plus celecoxib elicits antitumor immunity
Cancer Vaccine - SSX-2-derived epitope recognized by CD4+ T cells along with HLA-DR
Cancer Vaccine - Tumor cell-based vaccines are potent activators of CD4+ T lymphocytes
Candidiasis - Candida in concentrated oral rinse cultures detected by real-time PCR
Cervical Cancer - HPV vaccine targeting women age 24-45 is under study
Cervical Cancer - Imaging technology differentiates lesions, provides tumor biology insight
Cervical Cancer - Keratins 8, 10, 13, and 17 are useful diagnostic tumor markers
Cervical Cancer - Mechanism of HPV oncogene regulation of tumorigenesis described
Cervical Cancer - P73 expression associated with cellular radiosensitivity after radiotherapy
Chemokines - Upregulated MIF increases angiogenic factor levels in neuroblastoma
Childhood Adrenocortical Tumors - U.S. researchers report on childhood adrenocortical tumors
Clinical Genetics - Genetic profiling has advanced our knowledge of non-small cell lung cancer
Clinical Trials - NCI selects research organization to support preclinical studies
Coagulation Therapy - Novel tissue factor pathway inhibitor peptide obstructs tumor growth
Collaborations - Biopharma signs agreement to manufacture Coley's Toxin cancer vaccine
Collaborations - Cancer therapeutics alliance formed
Collaborations - Companies agree to develop and commercialize VX-680 for cancer
Collaborations - Europroteome enters molecular profiling collaboration
Collaborations - Geron announces agreement to conclude collaboration
Collaborations - Leukemia groups to expand patient services through Canada
Colorectal Cancer - Total vitamin D but not dietary alone prevents cancer
Complementary & Alternative Medicine - Black cohosh extract doesn't induce endometrial tumor growth in rat study
Coronary Artery Bypass Graft Surgery - KTX 0101 studied for prevention of cognitive impairment in CABG surgery patients
Coronary Heart Disease - Prostate cancer and coronary heart disease share some risk factors
Cutaneous T-Cell Lymphoma - Targretin cutaneous T-cell lymphoma therapy reimbursed by Medicare
Cytomegalovirus - Graft outcome with CMV prophylaxis depends on donor/recipient antibody status
DNA Vaccine - Heat-shock protein as dendritic cell target enhances vaccine potency
Dermatology - Melanocytes express 3G5 surface antigen
Diagnostics - Dynamic contrast-enhanced MRI shows how angiostatic drugs erase angiogenesis
Diet & Nutrition - Healthy eating and living can indeed reduce women's risk of getting cancer
Diet and Nutrition - Plant estrogens in soy don't appear to increase breast or uterine cancer risk
Drug Development - HKI-272 shows promise as breast cancer therapy
Drug Development - Liposomal formulation of OSI-7904 has improved efficacy
Drug Development - The novel Escherichia coli YeiK gene product is a gene therapy candidate
Drug Resistance - Bcl-2 antisense agent G3139 invokes a response to refractory multiple myeloma
Drug Resistance - Paclitaxel resistance in ovarian cancer patients likely multifactorial
Endometrial Cancer - Animal research suggests that stress may increase risk of uterine cancer
Endometrial Cancer - CYP17 and CYP19 genetic polymorphisms may play role in carcinogenesis
Endometrial Cancer - Correlation found among endocrine receptors in tumors and eutopic endometria
Endometriosis - Endometrial cells can originate from donor-derived bone marrow cells
Environmental Toxicology - Dothistroma needle blight of pines produces dothistromin, a carcinogenic toxin
Enzymology - Heparanase has a direct effect on angiogenesis
Finance - Biomarker company forecasts second-quarter revenue drop
Finance - Device company files past-due financial reports
Finance - Diagnostics company added to Russell 3000 Index, Merrill Lynch Nanotech Index
Finance - Diagnostics developer added to Russell 3000 Index, Merrill Lynch Nanotech Index
Finance - Paxis parent adopts stock repurchase plan
Ganglioglioma - Cerebral blood volume test can help determine glioma type
Gastroenterology - Neuropilin-1 is an angiogenesis induction factor in human colon cancers
Genetic Risk Factor - c-MPL gene mutations generate familial essential thrombocytosis
Genetics - Harvard patent on genetically altered mouse upheld
Genomics and Genetics - ChIP microarrays can identify genes silenced in cancer
Glioblastoma - Data published on telomerase inhibitor GRN163 in rodent models of brain tumors
Gynecology - Arias-Stella reaction of the endocervix characterized
Health Risk - Health officials say consult UV index to prevent sunburn
Hematological Oncology - Imatinib therapy reverses bone marrow angiogenesis in leukemia patients
Human Papillomavirus - Study suggests first molecular target to halt spread of HPV
Human Papillomavirus Vaccine - Dendritic cells expressing HPV16-E7 inhibited by co-expression of IL12
Human Papillomavirus Vaccine - Hypervariable epitopes induce immune responses against papillomaviruses
Human Papillomavirus Vaccine - Presentation system improves cellular immunity against papillomavirus
Imaging - Emory announces first clinical use in the U.S. of new On-board Imager
Immune Therapy - Rhabdomyosarcomas potential target of MAGE-specific immunotherapies
Immunology - Anti-CD30-scFv-Fc-IL-2 fusion induces resting NK cells to lyse lymphoma cells
Immunology - Bcl-2 expression is strongest prognostic factor of survival in B-cell lymphomas
Immunology - CD40 ligand gene therapy halts Th2-mediated tumor escape
Immunology - Impaired IFN-alpha-production of DCs may contribute to ATL immunodeficiency
Immunosuppression - Rapamycin targets tumors but protects allografts from rejection
Legal Issues - Securities class action suit filed against Genta Incorporated
Leukemia - Complex chromosomes not always associated with rapid disease evolution in MDS
Leukemia - Researchers report on HOX expression's association with biologic subset of AML
Liver Metastases - Researchers report on liver metastases resection procedures
Longevity - Croatian skeletons reveal changing status of cancer in Europe over time
Lung Cancer - Biotechnology company announces Tarceva was accepted into FDA's Pilot 1 Program
Lung Cancer - Brochure helps patients better understand radiation therapy
Lung Cancer - Depression coping associated with shorter survival in lung cancer study
Lung Cancer - INGN 241 with radiation inhibits tumor growth in animal model lung cancer study
Lung Cancer - New data suggest FUS1 therapy may play role in preventing onset of lung cancer
Lung Cancer - Observations from European clinical trials of TC-99M Hynic-Annexin released
Medical Imaging - Chromatography technique can be applied to anti-cancer drugs
Medical Technology - FDA clearances granted for software to review multi-detector CT chest exams
Melanoma - Phase 2 clinical trial studying anti-tumor activity of Talabostat initiated
Mergers & Acquisitions - AltaGen Biosciences acquired by biological products company
Mergers & Acquisitions - Cephalon reports agreement in principle with FTC staff on proposed merger
Mergers and Acquisitions - Brachytherapy seed developer announces merger
Mergers and Acquisitions - Medical device manufacturer extends merger discussions
Mergers and Acquisitions - Oncology drug development company to merge with biotechnology company
Metastasis - Hypoxia-inducible factors enhance cancer cell dissemination mechanisms
Metastasis - Metacept-1 and oxamflatin hinder cancer cell invasion and dissemination
Multiple Myeloma - Preclinical data on huN901-DM1 in multiple myeloma published in cancer journal
Myeloma - VEGF receptor inhibitor GW654652 discourages multiple myeloma metastasis
Nausea - FDA approval granted for Promethazine Hydrochloride tablets
Neuroblastoma - Amplifications in chromosome arm 1p identified
Omega-3 Fatty Acids - Health-promoting Omega-3 fatty acids may be produced in bioengineered plants
Oncogenes - Cancer gene MYC emerging as key research target
Oncology - Oncology drugs dominate pharmaceutical pipelines
Oncology - Proteo-genomics system identifies malignant antibody targets
Oncovirus - Heme oxygenase-1 is a therapeutic target for the treatment of Kaposi sarcoma
Ovarian Cancer - Dose-intense triplet chemotherapy with PBPC support investigated
Ovarian Cancer - Molecules that promote OC dissemination id'd by Drosophila genetic analysis
Ovarian Cancer - NF kappa B inhibition increases cisplatin efficacy in ovarian cancer models
Ovarian Cancer - Proposed disease model is based on morphological and molecular genetic analysis
Pancreatic Cancer - Ad/TRAIL-F/RGD may be potent therapeutic agent for pancreatic cancer
Pancreatic Cancer - Initial clinical data from GVAX pancreatic cancer vaccine program
Pancreatic Cancer - Positive CoFactor results reported in pancreatic tumor model
Pediatrics - PHOX2B gene mutations are not associated with sudden infant death syndrome
Peripheral Blood - Melanoma peptide cocktail generates T cells against malignant melanoma
Personnel - Biopharmaceutical company appoints vice president, director France
Personnel - Biotech company appoints Sara A. Courtneidge to advisory board
Personnel - CRO announces further expansion of its West Coast operations
Personnel - Gerhard Baumgartner joins Chemophase maker's scientific advisory board
Personnel - Synta appoints three physicians to oncology advisory board
Polio - Vaccine scandal revives cancer fears
Product Licensing - Spire receives catheter license payment from Bard
Prostate Cancer - Antigen may play role in treatment decisions
Prostate Cancer - Lifestyle changes can help prevent prostate cancer
Prostate Cancer - NDA submitted for Xinlay in the U.S.
Prostate Cancer - Novel candidate oncogene identified
Prostate Cancer - Study examines at-risk men's decision-making on prostate cancer screening
Pulmonary Medicine - Nucleotide insertions reverse the cystic fibrosis phenotype in tissue cultures
Radiation Oncology - Emory pioneers robotic system for precision radiation treatments
Radiation Therapy - Case report highlights risk of chemotherapy-induced radiation recall colitis
Restructuring - Drug-discovery company to focus resources on expanding clinical pipeline
Retrovirus Infection - HTLV-I infection may modify DPB pathogenesis via T cell activation
Smoking Ban - Ireland health minister vows to crush pub's rebellion against smoking ban
Smoking Ban - Statewide indoor smoking ban begins in Massachusetts
Solid Tumors - Phase I trial of CF101 with chemotherapy initiated
Stem Cell Research - Double labeling method measures cell turnover rates in colon
Stem Cell Transplantation - Deletion of chromosome band 13q14 prognostic factor in multiple myeloma with SCT
Stem-Cell Research - AML1-ETO in hematopoietic stem cells preferentially enhances their maintenance
Stem-Cell Research - Jagged1-induced Notch signaling drives multiple myeloma cell proliferation
Stem-Cell Research - L3MBTL implications for pathogenesis of myeloid malignancy 20q deletions
Stem-Cell Research - SCL required for normal function of short-term repopulating hematopoietic SCs
Stem-Cell Research - Type I HBEC immortalization may be early step in breast cancer subset initiation
Stem-Cell Transplantation - Acute gastrointestinal GVHD diagnosed frequently after allogeneic HCT
Stem-Cell Transplantation - CSP/MMF in URD HSCT patients acceptable toxicity but high rates of GVHD
Stem-Cell Transplantation - Chimeric CD19 Ab is option in post-transplant minimal residual B-lineage ALL
Stem-Cell Transplantation - EBV viral load monitoring best used to enable prompt treatment of PTLDs
Stem-Cell Transplantation - HSC source should be considered based on data for individual ethnic populations
Stem-Cell Transplantation - Severe cGVHD characterized by high CD4+ cells relative to central memory cells
Therapeutics - Sloan-Kettering to research positive health impacts of flower pollen extract
Tumor Suppression - Loss of LGI1 gene activity encourages glioma invasion
Vascular Diseases - Educational level is inversely associated with mortality
Vascular Targeting - FDA clears IND for Exherin
Vector Development - Human serum albumin nanoparticles deliver antisense nucleotides to tumor cells
Vector Development - Scalable production platform for oncolytic adenoviral vectors developed
Virology - Human herpesvirus type 8 and HCV coinfections show differential transmission
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