Cancer Weekly

Genomics and Genetics - Ensemble decision approach improves identification of disease-linked genes

Graft Versus Host Disease - DC stimulation of donor CD8+ T cells may be useful for prevention of GVHD

Gynecologic Cancer - SLN biopsy practicable for diagnosing cervical, endometrial cancers

Gynecologic Oncology - Peritoneal washing cytology as a diagnostic and prognostic tool reviewed

Gynecology - Prostaglandin EP₂ receptor mediates endometrial cancer angiogenesis

HIV/AIDS-Related Disease - BCL-6 mutations seen in HIV-related pulmonary lymphoproliferative disorders

HIV/AIDS-Related Disease - HAART increases survival of patients with HIV-associated Hodgkin disease

Head and Neck Cancer - Protein collusion foretells poor prognoses for maxillary sinus cancer patients

Hematologic Malignancy - Notch-1 signaling mediates BMS influence on hematologic malignant cell growth

Hematopoietic Disease - Malignant hematopoietic disease from internal exposure to Pu-239 uncertain

Hepatocellular Carcinoma - Kinectin splicing in HCC characterized

Hepatocellular Carcinoma - PIN1 overexpression/beta-catenin gene mutations distinct oncogenic events in HCC

Hepatocyte - Cancer-preventive geranylgeranoic acid occurs naturally in medicinal herbs

Hepatology - TWEAK expression may play a central role in liver cancer proliferation

Human Papillomavirus Vaccine - DNA microarray format for subtyping human papillomavirus developed

Immunology - New findings in lymphangiogenesis research provide targets for novel therapies

Immunology - Sunscreen immune protection factors determined using dendritic cell suspensions

Immunotherapy - Company files supplemental application for expanded use of BEXXAR

Laryngeal Cancer - France has high rate of laryngeal cancer mortality among European countries

Legal Issues - Plaintiffs fight for $10.1 billion judgment against Philip Morris

Legal Issues - Settlement and license agreement ends paclitaxel litigation

Leukemia - Gene profiles could improve acute leukemia diagnosis

Leukemia - Links Fore Leukemia raises $300,000 for The Leukemia & Lymphoma Society

Leukemia - Variant MYST4-CBP gene fusion found in t(10;16) acute myeloid leukemia

Leukemogenesis - Mechanism of leukemogenesis described

Leukemogenesis - Molecular mechanisms of leukemogenesis by AML1/EVI-1 described

Lung Cancer - Brochure helps lung cancer patients better understand treatment

Lung Cancer - Recoverin could be immunotherapy target

Lung Cancer - Upregulated genes identified in ACTH-producing SCLC tumors

Lung Cancer Risk Factor - Coal burning and genetics linked to lung cancer in Xuan Wei, China

Lymphoma - Chromosomal aberration patterns differ in two lymphoma subtypes

Malignant Mesothelioma - Novel chemotherapeutic agents promising for malignant mesothelioma

Medical Devices - Immunohistochemical test improves murine hypoxia gradient detection

Melanoma - Researchers use human antibody to cure malignant melanoma in mice

Melanoma - Study results suggest that lumican inhibits melanoma progression

Melanoma - Treatment with 5-FU and celecoxib helps reduce UVB-induced skin tumors in study

Mergers & Acquisitions - Canadian biotech company acquires NewBiotics Inc.

Mergers and Acquisitions - Acquisition of Integrity Healthcare Services complete

Metastasis - S100A4 triggers a pro-metastatic cascade in tumors

Metastasis - The effects of chemokines on tumor invasion are not fully understood

Metastatic Cancer - Active PAI-1 expression reduces invasive breast, gynecologic cancer phenotypes

Molecular Diagnostics - MGB Eclipse Detection Reagents launched

Muir-Torre Syndrome - Dermatopathologists play role in diagnosis of Muir-Torre syndrome

Multiple Myeloma - Intensive chemotherapy alone most cost effective option for stage II/III MM

Multiple Myeloma - Phase I trial to investigate 17-AAG in multiple myeloma patients

Mutagenesis - Aprataxin mutations cause early onset ataxia

Myelodysplastic Syndromes - Vidaza U.S. commercial launch announced

Myeloma - Thalidomide's promising future in fighting cancer explored

Neurology - Study reveals positive response of relapsed or refractory PCNSL to topotecan

Neuroscience - Coadministration of Pgp inhibitors improves docetaxel penetration into brain

Neuroscience - IL-1alpha and IL-6 protect neuronal SH-SY5Y cells from oxidative damage

Oncogene - p21-dependent cell cycle arrest guards against unrestricted cell proliferation

Oncogenes - Findings suggest need for new view of p53 cancer protein's interaction with DNA

Oncogenes - P13K signaling essential for ABL oncogene-mediated B cell transformation

Oncogenesis - Raf and RhoA cooperate to transform intestinal epithelial cells

Oncogenesis - The kinase inhibitor p27Kip1 is deregulated in thyroid cancer

Oncogenesis - Werner syndrome protein protects the genome from carcinogenic events

Oncology - Hypoxia-inducible factors regulate prolyl hydroxylases

Oncology - Thiadiazole urea inhibitors bind selectively to stromelysin-1

Oral Squamous Cell Carcinoma - Marijuana use not associated with oral squamous cell carcinoma risk in study

Organ Rejection - FDA grants permission for TAFA-93 clinical trial

Osteosarcoma - HER-2 oncogene overexpression does not play role in osteosarcomas

Osteosarcoma - Mepact granted Orphan Medicinal Product Designation in E.U. for osteosarcoma

Ovarian Cancer - IND, SPA submitted to FDA for pivotal trial of XYOTAX

Ovarian Cancer - Study finds ovarian cancer biomarker; potential screening breakthrough

Personnel - Biopharmaceutical company appoints vice president, clinical development

Personnel - Biotech company names Franklin Berger to board of directors

Personnel - Diagnostics developer announces organization changes, officer appointments

Personnel - Pharmaceutical company appoints new member to executive board

Personnel - Philip Livingston, MD joins advisory board

Personnel - Proteomics company names Dr. Wenpei Su as director of genomics applications

Pharmacogenetics - Pharmacogenetics can improve identification of high-risk ALL patients

Pharmacokinetics - Liquid chromatography/tandem mass spectrometry quantifies SU5416 E-isomer

Prenatal Genetic Testing - Multiple endocrine neoplasia 2A complications rare with early diagnosis

Prostate Cancer - Children's Hospital Boston awarded over $500,000 for prostate cancer research

Prostate Cancer - Focal cryotherapy for prostate cancer may offer benefits over current treatments

Prostate Cancer - Hormone refractory prostate cancer trial extended to additional Canadian sites

Prostate Cancer - New evidence shows Her-2/neu receptor correlates with prostate cancer risk

Proteomic Research - Advances in proteomic research may lead to early diagnosis of tumors, diseases

Proteomics - Hypoxia-inducible factor 1 facilitates a number of human pathologies

Renal Cancer - Initiation of Xcytrin Phase 2 clinical trial in renal cell carcinoma announced

Rhabdomyosarcoma - Novel t(2;20)(Q35;p12) seen in childhood RMS with embryonal histology

Rib Lesions - Gamma probe may help orthopedic surgeons with rib abnormality biopsies

Skin Cancer - CDKN2A/ARF gene mutation insignificant risk of FMM or MM in cancer aggregates

Skin Cancer - FDA approval granted for Aldara for superficial basal cell carcinoma

Skin Cancer - Oxidative stress/antioxidant network provide rationale for skin cancer treatment

Skin Carcinogenesis - Increased skin pigmentation may explain photoprotective properties of black skin

Skin Damage - Green tea polyphenols prevent ultraviolet light-induced oxidative damage

Small Cell Lung Cancer - Published study reports on radiation therapy for small cell lung cancer

Smoking Ban - Smoking ban goes into effect in Greenbrier County, West Virginia

Stem Cell Research - PF4 enhances normal/leukemic stem/progenitor cell adhesion to endothelial cells

Stem Cell Research - TNF-alpha suppresses GVHR by inhibiting IFN-gamma-dependent donor type-1 immunity

Stem Cell Transplantation - ATG added to conditioning regimen improves outcome in unrelated donor SCT

Stem Cell Transplantation - Combined stratification of refractory anemia improves prognosis in SCT

Stem Cell Transplantation - Donor treatment with pegylated G-CSF promotes transplantation tolerance

Stem Cell Transplantation - Encephalopathy in pediatric patients after HSCT associated with poor prognosis

Stem Cell Transplantation - GVHD major predictive factor for response to donor lymphocyte infusions in MM

Stem Cell Transplantation - Infused autograft lymphocyte dose affects clinical outcome post-SCT in MM

Stem Cell Transplantation - Infused cell dose predictive of outcomes after unrelated cord blood transplant

Stem Cell Transplantation - Primary systemic amyloidosis patients have increased survival following PBSCT

Stem Cell Transplantation - Steroid and cyclosporine A use are risk factors for bone loss following SCT

Testicular Infection - Early diagnosis and treatment paramount in P. boydii infections

Transplant Medicine - Study sets best time for bone marrow transplant in patients with blood disorder

Tumor Suppression - RUNX3 is a bona fide tumor suppressor of gastric cancers

Tumor Suppression - Reduced menin encourages intestinal cell tumorigenesis

Tumor Suppression - Vascular normalization improves drug penetration in tumors

Tumor Suppression - p300 and CBP are suppressors of hematological tumor formation

Tumor Suppressor Gene - Somatic inactivation of Nfl induces a progressive myeloproliferative disorder

Tumorigenesis - Brca1 and Chk2 have collaborative roles in tumorigenesis

Women's Health - CDC progam seeks to reduce risk of chronic diseases in disadvantaged women