Oncogenes
P13K signaling essential for ABL oncogene-mediated B cell transformation
Published in Cancer Weekly, August 3rd, 2004
According to recent research from the United States, "BCR-ABL and v-ABL are oncogenic forms of the Abl tyrosine kinase that can cause leukemias in mice and humans. ABL oncogenes trigger multiple signaling pathways whose contribution to transformation varies among cell types."
"Activation of phosphoinositide 3-kinase (P13K) is essential for ABL-dependent proliferation and survival in some cell types, and global P13K inhibitors can enhance the antileukemia effects of the Abl kinase inhibitor imatinib.
"Although a significant fraction of...
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Source: Cancer Weekly (2004-08-03)
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