Susan Hasty, Publisher
Table of Contents . . . August 10th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Cancer Weekly | Other Publications
Melanoma - Scientists identify molecular link driving spread of skin cancer
Ovarian Cancer - Study shows reports new diagnostic test is 100% effective
Ovarian Cancer - Tumor-derived DNA can be detected in some patients' plasma
Prostate Cancer - Link established between key protein and aggressiveness of prostate cancer
Signet-Ring Cell Carcinoma - Immunohistochemical staining distinguishes SRCC of stomach/breast/colon
Acute Myeloid Leukemia - Gene profiles could improve AML diagnosis, provide insight on better treatments
Adenosquamous Cancer - Hepatic ASC treated with TACE using degradable starch microspheres
Air Pollution - Maximum levels of benzene found at traffic stops and gas stations in Mumbai city
Anti-Infectives - Terbinafine and amphotericin B effective against Fusarium infection
Antiviral Therapy - Novel glycolipids rally host defense mechanisms against viral hepatitis
Apoptosis - Cytomegalovirus infection blocks apoptosis in cancer cells
Apoptosis - Nonylphenol induces apoptosis via Fas/FasL pathway by mimicking estrogen
Biochemistry - Microplate assays supply large-scale analyses of non-heme iron
Biological Therapy - The pleiotropic effects of flavopiridol enhance its antitumor properties
Bladder Cancer - Bladder-sparing treatment shows promise against cancer
Brain Cancer - Combining brain cancer treatments can give patients more time
Breast Cancer - Ablation therapy destroys tumors without scarring
Breast Cancer - Analytes in nipple aspirate fluid may have potential as cancer risk indicators
Breast Cancer - Brachytherapy saves breast, decreases treatment time
Breast Cancer - Breast-feeding associated with reduced risk of breast cancer in BRCA1 carriers
Breast Cancer - Collaboration aims to discover, develop diagnostic tests
Breast Cancer - Computers significantly increase tumor detection rate
Breast Cancer - DNA methylation predicts hormonal/nonhormonal breast cancer therapy response
Breast Cancer - Detection method overcomes problem of samples with few cells
Breast Cancer - Effects of linoleic acid on tumor cells characterized
Breast Cancer - False-negatives for sentinel node positivity increase in breast cancer staging
Breast Cancer - Grant received to study interaction between breast cancer cells and other cells
Breast Cancer - High treatment costs, stigma prevent women in Zambia from seeking care
Breast Cancer - High-dose chemotherapy: No greater survival benefit for high-risk patients
Breast Cancer - New imaging technology could save more women's lives
Breast Cancer - Optical probe might find what needle biopsies miss
Breast Cancer - Radiologist says annual reminder needed for mammography
Breast Cancer - Rates of ER-alpha expression do not differ between low- and high-risk cancers
Breast Cancer - Simple test identifies early-stage disease
Breast Cancer - Study shows how hCG decreases proliferation and invasion of MCF-7 cells
Breast Cancer - Study suggests broader chemotherapy attack may be more effective
Breast Cancer - The hottest sentinel lymph node is not always the positive node
Breast Cancer Vaccine - IL-12-engineered allogeneic cell vaccine prevents breast cancer
Breast Cancer Vaccine - Method to quantify immune response in cancer patients developed
Business & Finance - Pharmaceutical company reports stockholder approval of proposals, announces plans
Business & Finance - Therapeutics company announces preliminary year-end results
Business Update - Microarray technology licenses to the University of Nottingham
Cancer - Memorial foundation helps fund cancer support system in Washington, D.C., Area
Cancer Prevention - Research shows women who followed AICR guidelines cut their cancer risk
Cancer Prognosis - Physical symptoms appear to predict cancer course
Cancer Research - Biopharmaceutical company announces studies presented at SPORE meeting
Cancer Research - Food and drug retailer funds professorship for prostate cancer research at UCSF
Cancer Risk - Harvard study shows some caulking may be linked to cancer
Cancer Risk Factor - COX-2 gene sequence variation influences the formation of prostate cancer
Cancer Screening - More research, education about complexities of BRCA1/2 genetic testing
Cancer Therapy - Antimutagenic activity of bifidobacteria vary with acid/bile treatment
Cancer Therapy - Biopharma company announces positive results for PBI-1393 in cancer therapy
Cancer Therapy - Biotechnology company announces collaborative research agreement
Cancer Therapy - Companies ink agreement to develop Panzem clinical material
Cancer Therapy - Fatigue may be due more to depression than chemotherapy side effects
Cancer Therapy - Hemicorporectomy can resolve chronic pressure ulcer carcinoma
Cancer Therapy - High doses of statins may prevent tumor progression
Cancer Therapy - INX-0167 has potential to enhance anti-tumor activity of monoclonal antibodies
Cancer Therapy - Researchers identified carbohydrate that assists in killing of cancer cells
Cancer Therapy - Sponge substance works well with yew derivative against cancer cells
Cancer Therapy - Ultrasound-released micelle-encapsulated drugs show promise
Cancer Therapy - Vet school professor using gene therapy to battle cancerous tumors
Cancer Therapy - X-ray crystal structure of a human histone deacetylase published
Cancer Threat - U.S. CDC says asbestos deaths keep rising
Cancer Vaccine - CXCR3 plays pivotal role in melanoma cell metastasis to lymph nodes
Cancer Vaccine - MAGE-1 peptide recognized by T cells on HLA-B*5701 tumors identified
Cancer Vaccine - Profile of tumor antigens on breast and pancreatic cancer cells created
Cancer Vaccine - Progress on new vaccine strategies to treat and prevent cancer reviewed
Carcinogenesis - Molecular simulations analyze the benzene-derived DNA adduct pBQ-C
Cell Death - Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells
Cervical Cancer - Australia recognizes new use for high-risk HPV testing
Cervical Cancer - Income, education linked to outcome
Chemotherapy - Angiopoietin decoy alters angiogenesis to stop tumors
Clinical Trials - Genetics company picks Albany Molecular to make drug-linker system
Collaborations - Agreement renewed to supply cell separation technology
Collaborations - Deal signed for the discovery of cancer treatment efficacy markers
Collaborations - GE and Celera announce personalized medicine collaboration
Collaborations - License granted to Genentech to patent portfolio of an oncology target
Collaborations - Oncology product targeting epidermal growth factor receptor licensed
Collaborations - UCLA, imaging company collaborate on breast imaging
Colon Cancer - Angiogenic differences explain the morphology of early colorectal cancers
Colon Cancer - Fecal DNA testing simple and effective
Colon Cancer - Immunotoxin linked to monoclonal Ab or C5 cytotoxic against colon cancer cells
Colon Cancer - New targeted therapy for treatment of resistant colorectal cancer
Colon Cancer - XOS and FOS dietary supplementation may promote gastrointestinal health
Complementary & Alternative Medicine - Curcumin induces apoptosis in lung cancer cells
DNA Damage - UV-dependent alternative splicing uncouples p53 activity and PIG3 gene function
Diagnostics - Cancer diagnostics company attracts significant interest
Diagnostics - Central America sales distribution agreement inked for ComfortScan system
Diagnostics - FDA approval granted for computer-aided detection system for lung nodules
Diagnostics - Image-guided tracking feature expands clinical applications for tumor imaging
Diagnostics - Personalized medicine company wins CLIA approval for clinical laboratory
Diagnostics - RadNet Management selects computer-aided detection system for breast MRI
Diagnostics - Spiral CT scanning favorable for detection of small sized lung cancers
Disease Associations - Lipid peroxidation derivatives inhabit cancer-prone livers
Disease Associations - Oxygen imbalance governs atherosclerosis and cancer angiogenesis
Drug Development - Drug company has phase 2 study results of Dacogen in MDS patients published
Drug Development - Drug company releases DJ-1 predictive diagnostic for Parkinson disease
Drug Development - IFIX is a new interferon-inducible HIN-200 gene with anticancer properties
Drug Development - Novel anti-cancer taxoids synthesized
Drug Development - U.S. Treasury approves bioscience, cancer drug companies Cuban products purchase
Drug Uptake - Murine models optimize high voltage-assisted drug delivery
Electronic Medical Records - Sutter Health picks Siemen's PACS for digital X-ray imaging
Endocrinology - Parathyroid proliferative lesions contain increased neovascularization
Endometrial Cancer - Study investigates possible mechanism by which tamoxifen promotes disease
Epidermal Hyperplasia - Potentiation of UVB-induced apoptosis by novel phytosphingosine derivative studied
Esophageal Cancer - Additional microvascular anastomosis improves esophageal reconstruction
Esophageal Cancer - Novel stent suitable for palliative treatment
Finance - Drug developer raises $32 million to fund advancement of lead product candidates
Finance - Glycobiology company inks agreement to close on $5,000,000 of funding
Finance - Oncology drug development company reports second quarter financial results
Finance - Oncology systems company expects solid growth in third quarter of fiscal 2004
Finance - Oncology therapeutics company reports second quarter 2004 financial results
Finance - Therapeutics company reports second quarter increase in product sales
Funding - Billionaire Buffett and wife donate $6 million to hospitals for cancer research
Gene Probes - Sequence-matched probes of breast cancer cells produce data consistency
Gene Profiling - Modified suppression subtractive hybridization detects tumor suppressor genes
Gene Transfer - Replication-competent viruses offer a way to disseminate cancer therapy
Genomics - Bioresearch companies publish atomic structure of human histone deacetylase
Genomics - Survey shows perception of diagnostics for family of patient with genetic cancer
Genomics & Genetics - BMT for therapy-related AML in acute RB associated with 13q deletion syndrome
Glioma - Concurrent RNA interference reduces brain cancer proliferation
HIV/AIDS - Company reports negative results for phase III HIV/AIDS study
Head and Neck Cancer - Possible molecular HNSCC biomarkers identified
Helicobacter Pylori - Scientists discover new intricacies in how ulcer bugs stick to stomach
Hepatitis - Preclinical data presented on anticancer agents, immunomodulatory molecules
Hepatology - Ethnicity, gender, and age influence the formation of primary liver cancer
Herpesvirus - Herpesvirus protease inhibited by dimer disruption
Herpesvirus - KSHV-encoded latency-associated NA inhibits lytic replication by targeting Rta
Herpesvirus - Kaposi sarcoma-associated herpesvirus GP K8.1 is dispensable for virus entry
Hodgkin Disease - Epidemiology of Hodgkin disease requires further study
Human Papillomavirus Vaccine - Two novel human papillomavirus-16 E7 T helper epitopes identified
Immunology - Patients' cells from tumors, immune system merged for customized cancer therapy
Immunotherapy - Cripto is novel target for antibody-based cancer immunotherapy
Information Technology - Computer-aided software system for lung nodule detection receives FDA approval
Legal Issues - Judge fines Philip Morris for deletion of e-mails
Legal Issues - Judge refuses to drop Hanford downwinders from lawsuit
Leukemia - Genes linked to AML pathogenesis identified
Leukemia - HLA-A2 class I monomers may be used against leukemia-associated protein
Leukemia - New research has implications for mechanisms of VDJ recombination
Leukemia - Newly discovered property of leukemia cells may lead to novel treatment
Leukemia - PR CpG island aberrant hypermethylation may be genetic alteration in leukemia
Leukemia Vaccine - Peptide immunogens mimic coiled region of T-cell leukemia virus subunit
Liver Cancer - Chronic inflammation contributes to the formation of hepatocellular carcinoma
Liver Cancer - Hepatitis B virus X protein modulates Wnt/beta-catenin in hepatoma cells
Liver Cancer - Hepatocellular carcinomas contain effective immune escape mechanisms
Liver Cancer - PI-88 phase II clinical trial targeting liver cancer launched
Lung Cancer - Current smoking decreases survival of NSCLC patients following radiation therapy
Lung Cancer - Improvements in the therapy of small-cell lung cancer described
Lung Cancer - Phase II trials study Kahalalide F in lung cancer and melanoma
Lymphoma - Fast track designation issued for pixantrone
Lymphoma - Interleukin-12 receptor beta2 halts B cell malignancies
Lymphoma Therapy - Zevalin radioimmunotherapy produces durable responses
Medical Communication - Peer-reviewed stem cell journal launched online and in print
Melanoma - Removal of pigmented melanocytic volar skin lesions in children not recommended
Melanoma - Vaccine boosts immunity against cancer target
Mergers & Acquisitions - Healthcare industry supplier acquires provider of mammogram technology
Mergers & Acquisitions - Private umbilical cord blood stem cell banks merge
Metastasis - Anticoagulants interrupt metastatic events in solid tumors
Metastasis - Protein implicated in cancer spread
Metastatic Melanoma - Phase II trial to study 17-AAG in metastatic melanoma
Multipotent Cell Transplantation - Dermal multipotent cell transplant promotes recovery after sublethal irradiation
Nasopharyngeal carcinoma - Id1 induction by LMP1 may promote nasopharyngeal carcinoma of EBV-infected cells
Neuroscience - Hypoxia-inducible factor 1 is a biomarker for brain tumor status
Obesity Risk Factor - Matrix metalloproteinase 19-deficient mice at increased obesity risk
Oncogene - c-Fos mediates c-Myc-induced apoptosis in human liver cancer cells
Oncogenesis - Akt stimulates aerobic glycolysis in cancer cells
Oncogenesis - Interrupted angiogenesis attenuates liver cancer progression in mice
Oncogenesis - Strong mutator phenotypes are not required for malignant progression
Oncogenesis - p53 mutants induce oncogenesis by transactivating growth-promoting genes
Oncology - Eph receptor and ephrin ligand profiles predict cancer invasion
Oncology - Gene expression can be altered over large chromosomal regions
Oncology - Novel molecule mediates ErbB2-driven tumor cell motility
Oncology - Overexpressed SOX9 transcription factor foils prostate cancer growth
Oncology - Tumor hypoxia increases apoptosis resistance
Oral Cancer - Genes associated with aggressive disease identified
Oral Cancer - Secondary malignancy can emulate peri-implantitis
Oral Mucositis - Clinical study of MF5232 for oral mucositis drug yields positive results
Ovarian Cancer - Contrast-enhanced power Doppler ultrasound detects tumors noninvasively
Ovarian Cancer - Predictive factors identified for irresectability in advanced disease
Ovarian Cancer - RGnRH a potential chemotherapy target in patients with RGnRH+ tumors
Ovarian Cancer - Risk factors identified for different histological types of ovarian cancer
Palliative Care - Chemotherapy and supportive care are a winning combination
Pancreatic Cancer - High-resolution characterization of pancreatic adenocarcinoma genome achieved
Pancreatic Carcinoma - Chronic exposure to dioxin associated with pancreatic acinar adenoma, carcinoma
Patents - Company receives U.S. patent for topical treatment of radiation dermatitis
Patents - U.S. patent granted for cancer detection method
Peripheral Nerve Tumor - Diagnostic steps assist with safe removal of peripheral nerve tumor
Personnel - Biopharmaceutical company announces new board member
Personnel - Biotech company names Daniel J. O'Shannessy to newly created COO position
Personnel - Drug discovery company promotes Jeffrey Stafford to vice president of chemistry
Personnel - Gail K. Naughton, PhD, elected to board of disease-state management company
Personnel - Imaging company launches business advisory committee
Personnel - Linda Staley named vice president, IT for cancer biotech
Personnel - Loukas named VP, general counsel, corporate secretary of onco-focused biotech
Personnel - Matthews Media Group announces VP of oncology team, Smart Trials group
Personnel - Medical director named at Abbott Northwestern's Virginia Piper Cancer Institute
Personnel - Radiation therapy and patient assessment company appoints CFO
Pharmaceutical & Drug Development - Lymphocytes transformed by EBV-related HSV may be useful for antiviral screening
Pharmaceutical & Drug Development - Powerdental helps prevent and treat oral and inflammatory diseases
Pharmacology - The cytokine inhibitor ISIS 104838 extends bioavailability upon oral intake
Prognostic Indicator - Indicators predict survival/death in pediatric HSCT patients admitted to the ICU
Prostate Cancer - Novel gene linked to tumorigenesis
Prostate Cancer - Novel models quantify the effects of cancer therapy on angiogenesis
Prostate Cancer - Phase III trial of GVAX prostate cancer vaccine initiated
Prostate Cancer - Six-month prostate cancer data submitted for Canadian marketing authorization
Prostate Cancer - Zoledronic acid prevents SREs in hormone-refractory prostate cancer
Proteomics - Role of TACC1 protein in cytokinesis clarified
Proteomics - Several elements rule basic fibroblast growth factor interactions
Proteomics - VEGF receptor blockade arrests PKB/Akt protein activity in endothelial cells
Radiation Exposure - Diltiazem prevents gamma radiation-induced anemia
Radiotherapy - Plasma VEGF has limited value for assessing radiation-induced tumor changes
Regulatory Issues - FDA to establish new cancer office and program to speed drug approvals
Stem Cell Research - Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme
Stem Cell Transplantation - TNFA polymorphisms have functional effect on myeloid engraftment in HSCT
Tissue Bonding - Study: Thoracic surgery using biological tissue-bonding technology effective
Tobacco Use - Method to measure exhaled carbon monoxide levels assesses smoking status
Tumor Detection - MRI detects lung tumors using partial liquid ventilation with PFC/water emulsion
Tumor Growth - Chemokines involved in leukocyte infiltration of tumors
Tumor Suppression - Mus81 expression has critical role in genome integrity and tumor suppression
Tumor Suppression - The VEGF receptor-binding antagonist VGA1102 stalls in vivo tumor growth
Tumor Suppression - alpha-Tocopheryl succinate selectively suppresses proliferation of cancer cells
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.