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Cancer Weekly

Susan Hasty, Publisher

Table of Contents . . . August 10th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Cancer Weekly | Other Publications

Melanoma - Scientists identify molecular link driving spread of skin cancer

Ovarian Cancer - Study shows reports new diagnostic test is 100% effective

Ovarian Cancer - Tumor-derived DNA can be detected in some patients' plasma

Prostate Cancer - Link established between key protein and aggressiveness of prostate cancer

Signet-Ring Cell Carcinoma - Immunohistochemical staining distinguishes SRCC of stomach/breast/colon

Acute Myeloid Leukemia - Gene profiles could improve AML diagnosis, provide insight on better treatments

Adenosquamous Cancer - Hepatic ASC treated with TACE using degradable starch microspheres

Air Pollution - Maximum levels of benzene found at traffic stops and gas stations in Mumbai city

Anti-Infectives - Terbinafine and amphotericin B effective against Fusarium infection

Antiviral Therapy - Novel glycolipids rally host defense mechanisms against viral hepatitis

Apoptosis - Cytomegalovirus infection blocks apoptosis in cancer cells

Apoptosis - Nonylphenol induces apoptosis via Fas/FasL pathway by mimicking estrogen

Biochemistry - Microplate assays supply large-scale analyses of non-heme iron

Biological Therapy - The pleiotropic effects of flavopiridol enhance its antitumor properties

Bladder Cancer - Bladder-sparing treatment shows promise against cancer

Brain Cancer - Combining brain cancer treatments can give patients more time

Breast Cancer - Ablation therapy destroys tumors without scarring

Breast Cancer - Analytes in nipple aspirate fluid may have potential as cancer risk indicators

Breast Cancer - Brachytherapy saves breast, decreases treatment time

Breast Cancer - Breast-feeding associated with reduced risk of breast cancer in BRCA1 carriers

Breast Cancer - Collaboration aims to discover, develop diagnostic tests

Breast Cancer - Computers significantly increase tumor detection rate

Breast Cancer - DNA methylation predicts hormonal/nonhormonal breast cancer therapy response

Breast Cancer - Detection method overcomes problem of samples with few cells

Breast Cancer - Effects of linoleic acid on tumor cells characterized

Breast Cancer - False-negatives for sentinel node positivity increase in breast cancer staging

Breast Cancer - Grant received to study interaction between breast cancer cells and other cells

Breast Cancer - High treatment costs, stigma prevent women in Zambia from seeking care

Breast Cancer - High-dose chemotherapy: No greater survival benefit for high-risk patients

Breast Cancer - New imaging technology could save more women's lives

Breast Cancer - Optical probe might find what needle biopsies miss

Breast Cancer - Radiologist says annual reminder needed for mammography

Breast Cancer - Rates of ER-alpha expression do not differ between low- and high-risk cancers

Breast Cancer - Simple test identifies early-stage disease

Breast Cancer - Study shows how hCG decreases proliferation and invasion of MCF-7 cells

Breast Cancer - Study suggests broader chemotherapy attack may be more effective

Breast Cancer - The hottest sentinel lymph node is not always the positive node

Breast Cancer Vaccine - IL-12-engineered allogeneic cell vaccine prevents breast cancer

Breast Cancer Vaccine - Method to quantify immune response in cancer patients developed

Business & Finance - Pharmaceutical company reports stockholder approval of proposals, announces plans

Business & Finance - Therapeutics company announces preliminary year-end results

Business Update - Microarray technology licenses to the University of Nottingham

Cancer - Memorial foundation helps fund cancer support system in Washington, D.C., Area

Cancer Prevention - Research shows women who followed AICR guidelines cut their cancer risk

Cancer Prognosis - Physical symptoms appear to predict cancer course

Cancer Research - Biopharmaceutical company announces studies presented at SPORE meeting

Cancer Research - Food and drug retailer funds professorship for prostate cancer research at UCSF

Cancer Risk - Harvard study shows some caulking may be linked to cancer

Cancer Risk Factor - COX-2 gene sequence variation influences the formation of prostate cancer

Cancer Screening - More research, education about complexities of BRCA1/2 genetic testing

Cancer Therapy - Antimutagenic activity of bifidobacteria vary with acid/bile treatment

Cancer Therapy - Biopharma company announces positive results for PBI-1393 in cancer therapy

Cancer Therapy - Biotechnology company announces collaborative research agreement

Cancer Therapy - Companies ink agreement to develop Panzem clinical material

Cancer Therapy - Fatigue may be due more to depression than chemotherapy side effects

Cancer Therapy - Hemicorporectomy can resolve chronic pressure ulcer carcinoma

Cancer Therapy - High doses of statins may prevent tumor progression

Cancer Therapy - INX-0167 has potential to enhance anti-tumor activity of monoclonal antibodies

Cancer Therapy - Researchers identified carbohydrate that assists in killing of cancer cells

Cancer Therapy - Sponge substance works well with yew derivative against cancer cells

Cancer Therapy - Ultrasound-released micelle-encapsulated drugs show promise

Cancer Therapy - Vet school professor using gene therapy to battle cancerous tumors

Cancer Therapy - X-ray crystal structure of a human histone deacetylase published

Cancer Threat - U.S. CDC says asbestos deaths keep rising

Cancer Vaccine - CXCR3 plays pivotal role in melanoma cell metastasis to lymph nodes

Cancer Vaccine - MAGE-1 peptide recognized by T cells on HLA-B*5701 tumors identified

Cancer Vaccine - Profile of tumor antigens on breast and pancreatic cancer cells created

Cancer Vaccine - Progress on new vaccine strategies to treat and prevent cancer reviewed

Carcinogenesis - Molecular simulations analyze the benzene-derived DNA adduct pBQ-C

Cell Death - Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells

Cervical Cancer - Australia recognizes new use for high-risk HPV testing

Cervical Cancer - Income, education linked to outcome

Chemotherapy - Angiopoietin decoy alters angiogenesis to stop tumors

Clinical Trials - Genetics company picks Albany Molecular to make drug-linker system

Collaborations - Agreement renewed to supply cell separation technology

Collaborations - Deal signed for the discovery of cancer treatment efficacy markers

Collaborations - GE and Celera announce personalized medicine collaboration

Collaborations - License granted to Genentech to patent portfolio of an oncology target

Collaborations - Oncology product targeting epidermal growth factor receptor licensed

Collaborations - UCLA, imaging company collaborate on breast imaging

Colon Cancer - Angiogenic differences explain the morphology of early colorectal cancers

Colon Cancer - Fecal DNA testing simple and effective

Colon Cancer - Immunotoxin linked to monoclonal Ab or C5 cytotoxic against colon cancer cells

Colon Cancer - New targeted therapy for treatment of resistant colorectal cancer

Colon Cancer - XOS and FOS dietary supplementation may promote gastrointestinal health

Complementary & Alternative Medicine - Curcumin induces apoptosis in lung cancer cells

DNA Damage - UV-dependent alternative splicing uncouples p53 activity and PIG3 gene function

Diagnostics - Cancer diagnostics company attracts significant interest

Diagnostics - Central America sales distribution agreement inked for ComfortScan system

Diagnostics - FDA approval granted for computer-aided detection system for lung nodules

Diagnostics - Image-guided tracking feature expands clinical applications for tumor imaging

Diagnostics - Personalized medicine company wins CLIA approval for clinical laboratory

Diagnostics - RadNet Management selects computer-aided detection system for breast MRI

Diagnostics - Spiral CT scanning favorable for detection of small sized lung cancers

Disease Associations - Lipid peroxidation derivatives inhabit cancer-prone livers

Disease Associations - Oxygen imbalance governs atherosclerosis and cancer angiogenesis

Drug Development - Drug company has phase 2 study results of Dacogen in MDS patients published

Drug Development - Drug company releases DJ-1 predictive diagnostic for Parkinson disease

Drug Development - IFIX is a new interferon-inducible HIN-200 gene with anticancer properties

Drug Development - Novel anti-cancer taxoids synthesized

Drug Development - U.S. Treasury approves bioscience, cancer drug companies Cuban products purchase

Drug Uptake - Murine models optimize high voltage-assisted drug delivery

Electronic Medical Records - Sutter Health picks Siemen's PACS for digital X-ray imaging

Endocrinology - Parathyroid proliferative lesions contain increased neovascularization

Endometrial Cancer - Study investigates possible mechanism by which tamoxifen promotes disease

Epidermal Hyperplasia - Potentiation of UVB-induced apoptosis by novel phytosphingosine derivative studied

Esophageal Cancer - Additional microvascular anastomosis improves esophageal reconstruction

Esophageal Cancer - Novel stent suitable for palliative treatment

Finance - Drug developer raises $32 million to fund advancement of lead product candidates

Finance - Glycobiology company inks agreement to close on $5,000,000 of funding

Finance - Oncology drug development company reports second quarter financial results

Finance - Oncology systems company expects solid growth in third quarter of fiscal 2004

Finance - Oncology therapeutics company reports second quarter 2004 financial results

Finance - Therapeutics company reports second quarter increase in product sales

Funding - Billionaire Buffett and wife donate $6 million to hospitals for cancer research

Gene Probes - Sequence-matched probes of breast cancer cells produce data consistency

Gene Profiling - Modified suppression subtractive hybridization detects tumor suppressor genes

Gene Transfer - Replication-competent viruses offer a way to disseminate cancer therapy

Genomics - Bioresearch companies publish atomic structure of human histone deacetylase

Genomics - Survey shows perception of diagnostics for family of patient with genetic cancer

Genomics & Genetics - BMT for therapy-related AML in acute RB associated with 13q deletion syndrome

Glioma - Concurrent RNA interference reduces brain cancer proliferation

HIV/AIDS - Company reports negative results for phase III HIV/AIDS study

Head and Neck Cancer - Possible molecular HNSCC biomarkers identified

Helicobacter Pylori - Scientists discover new intricacies in how ulcer bugs stick to stomach

Hepatitis - Preclinical data presented on anticancer agents, immunomodulatory molecules

Hepatology - Ethnicity, gender, and age influence the formation of primary liver cancer

Herpesvirus - Herpesvirus protease inhibited by dimer disruption

Herpesvirus - KSHV-encoded latency-associated NA inhibits lytic replication by targeting Rta

Herpesvirus - Kaposi sarcoma-associated herpesvirus GP K8.1 is dispensable for virus entry

Hodgkin Disease - Epidemiology of Hodgkin disease requires further study

Human Papillomavirus Vaccine - Two novel human papillomavirus-16 E7 T helper epitopes identified

Immunology - Patients' cells from tumors, immune system merged for customized cancer therapy

Immunotherapy - Cripto is novel target for antibody-based cancer immunotherapy

Information Technology - Computer-aided software system for lung nodule detection receives FDA approval

Legal Issues - Judge fines Philip Morris for deletion of e-mails

Legal Issues - Judge refuses to drop Hanford downwinders from lawsuit

Leukemia - Genes linked to AML pathogenesis identified

Leukemia - HLA-A2 class I monomers may be used against leukemia-associated protein

Leukemia - New research has implications for mechanisms of VDJ recombination

Leukemia - Newly discovered property of leukemia cells may lead to novel treatment

Leukemia - PR CpG island aberrant hypermethylation may be genetic alteration in leukemia

Leukemia Vaccine - Peptide immunogens mimic coiled region of T-cell leukemia virus subunit

Liver Cancer - Chronic inflammation contributes to the formation of hepatocellular carcinoma

Liver Cancer - Hepatitis B virus X protein modulates Wnt/beta-catenin in hepatoma cells

Liver Cancer - Hepatocellular carcinomas contain effective immune escape mechanisms

Liver Cancer - PI-88 phase II clinical trial targeting liver cancer launched

Lung Cancer - Current smoking decreases survival of NSCLC patients following radiation therapy

Lung Cancer - Improvements in the therapy of small-cell lung cancer described

Lung Cancer - Phase II trials study Kahalalide F in lung cancer and melanoma

Lymphoma - Fast track designation issued for pixantrone

Lymphoma - Interleukin-12 receptor beta2 halts B cell malignancies

Lymphoma Therapy - Zevalin radioimmunotherapy produces durable responses

Medical Communication - Peer-reviewed stem cell journal launched online and in print

Melanoma - Removal of pigmented melanocytic volar skin lesions in children not recommended

Melanoma - Vaccine boosts immunity against cancer target

Mergers & Acquisitions - Healthcare industry supplier acquires provider of mammogram technology

Mergers & Acquisitions - Private umbilical cord blood stem cell banks merge

Metastasis - Anticoagulants interrupt metastatic events in solid tumors

Metastasis - Protein implicated in cancer spread

Metastatic Melanoma - Phase II trial to study 17-AAG in metastatic melanoma

Multipotent Cell Transplantation - Dermal multipotent cell transplant promotes recovery after sublethal irradiation

Nasopharyngeal carcinoma - Id1 induction by LMP1 may promote nasopharyngeal carcinoma of EBV-infected cells

Neuroscience - Hypoxia-inducible factor 1 is a biomarker for brain tumor status

Obesity Risk Factor - Matrix metalloproteinase 19-deficient mice at increased obesity risk

Oncogene - c-Fos mediates c-Myc-induced apoptosis in human liver cancer cells

Oncogenesis - Akt stimulates aerobic glycolysis in cancer cells

Oncogenesis - Interrupted angiogenesis attenuates liver cancer progression in mice

Oncogenesis - Strong mutator phenotypes are not required for malignant progression

Oncogenesis - p53 mutants induce oncogenesis by transactivating growth-promoting genes

Oncology - Eph receptor and ephrin ligand profiles predict cancer invasion

Oncology - Gene expression can be altered over large chromosomal regions

Oncology - Novel molecule mediates ErbB2-driven tumor cell motility

Oncology - Overexpressed SOX9 transcription factor foils prostate cancer growth

Oncology - Tumor hypoxia increases apoptosis resistance

Oral Cancer - Genes associated with aggressive disease identified

Oral Cancer - Secondary malignancy can emulate peri-implantitis

Oral Mucositis - Clinical study of MF5232 for oral mucositis drug yields positive results

Ovarian Cancer - Contrast-enhanced power Doppler ultrasound detects tumors noninvasively

Ovarian Cancer - Predictive factors identified for irresectability in advanced disease

Ovarian Cancer - RGnRH a potential chemotherapy target in patients with RGnRH+ tumors

Ovarian Cancer - Risk factors identified for different histological types of ovarian cancer

Palliative Care - Chemotherapy and supportive care are a winning combination

Pancreatic Cancer - High-resolution characterization of pancreatic adenocarcinoma genome achieved

Pancreatic Carcinoma - Chronic exposure to dioxin associated with pancreatic acinar adenoma, carcinoma

Patents - Company receives U.S. patent for topical treatment of radiation dermatitis

Patents - U.S. patent granted for cancer detection method

Peripheral Nerve Tumor - Diagnostic steps assist with safe removal of peripheral nerve tumor

Personnel - Biopharmaceutical company announces new board member

Personnel - Biotech company names Daniel J. O'Shannessy to newly created COO position

Personnel - Drug discovery company promotes Jeffrey Stafford to vice president of chemistry

Personnel - Gail K. Naughton, PhD, elected to board of disease-state management company

Personnel - Imaging company launches business advisory committee

Personnel - Linda Staley named vice president, IT for cancer biotech

Personnel - Loukas named VP, general counsel, corporate secretary of onco-focused biotech

Personnel - Matthews Media Group announces VP of oncology team, Smart Trials group

Personnel - Medical director named at Abbott Northwestern's Virginia Piper Cancer Institute

Personnel - Radiation therapy and patient assessment company appoints CFO

Pharmaceutical & Drug Development - Lymphocytes transformed by EBV-related HSV may be useful for antiviral screening

Pharmaceutical & Drug Development - Powerdental helps prevent and treat oral and inflammatory diseases

Pharmacology - The cytokine inhibitor ISIS 104838 extends bioavailability upon oral intake

Prognostic Indicator - Indicators predict survival/death in pediatric HSCT patients admitted to the ICU

Prostate Cancer - Novel gene linked to tumorigenesis

Prostate Cancer - Novel models quantify the effects of cancer therapy on angiogenesis

Prostate Cancer - Phase III trial of GVAX prostate cancer vaccine initiated

Prostate Cancer - Six-month prostate cancer data submitted for Canadian marketing authorization

Prostate Cancer - Zoledronic acid prevents SREs in hormone-refractory prostate cancer

Proteomics - Role of TACC1 protein in cytokinesis clarified

Proteomics - Several elements rule basic fibroblast growth factor interactions

Proteomics - VEGF receptor blockade arrests PKB/Akt protein activity in endothelial cells

Radiation Exposure - Diltiazem prevents gamma radiation-induced anemia

Radiotherapy - Plasma VEGF has limited value for assessing radiation-induced tumor changes

Regulatory Issues - FDA to establish new cancer office and program to speed drug approvals

Stem Cell Research - Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme

Stem Cell Transplantation - TNFA polymorphisms have functional effect on myeloid engraftment in HSCT

Tissue Bonding - Study: Thoracic surgery using biological tissue-bonding technology effective

Tobacco Use - Method to measure exhaled carbon monoxide levels assesses smoking status

Tumor Detection - MRI detects lung tumors using partial liquid ventilation with PFC/water emulsion

Tumor Growth - Chemokines involved in leukocyte infiltration of tumors

Tumor Suppression - Mus81 expression has critical role in genome integrity and tumor suppression

Tumor Suppression - The VEGF receptor-binding antagonist VGA1102 stalls in vivo tumor growth

Tumor Suppression - alpha-Tocopheryl succinate selectively suppresses proliferation of cancer cells

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