Antiviral Therapy

Novel glycolipids rally host defense mechanisms against viral hepatitis

Published in Cancer Weekly, August 10th, 2004

Novel glycolipids rally host defense mechanisms against viral hepatitis.

"Alpha-galactosylceramide is a glycolipid derived from marine sponges that is currently in human clinical trials as an anticancer agent. It has also been shown to be effective in reducing the amount of hepatitis B virus (HBV) DNA detected in mice that produce HBV constitutively from a transgene. It was assumed that all of the antiviral and antitumor activities associated with a-galactosylceramide were mediated through the activation of natural killer T cells," scientists in the United States report.

"However, we report here an additional unpredicted activity of...

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Source: Cancer Weekly (2004-08-10)

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