Ovarian Cancer

Tumor-derived DNA can be detected in some patients' plasma

Published in Cancer Weekly, August 10th, 2004

Tumor-derived DNA can be detected in the plasma of some ovarian cancer patients, researchers found in an evaluation use of plasma DNA analysis as a method for somatic mutation screening.

"Mutation of p53 is one of the most common genetic abnormalities detected in up to 81% of cases of ovarian cancer," said J. Otsuka and colleagues, Showa University, Japan.

For their study, the researchers first determined the presence of p53 mutations in plasma and in cancerous tissue of ovarian cancer patients. Then they "analyzed the plasma DNA for the presence of p53 mutations (exons 5-8)," they said.

"Of 27 cases of ovarian cancer, 12 cases...

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Source: Cancer Weekly (2004-08-10)

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