Disease Associations
Oxygen imbalance governs atherosclerosis and cancer angiogenesis
Published in Cancer Weekly, August 10th, 2004
"Tissue hypoxia occurs where there is an imbalance between oxygen supply and consumption in both solid tumors as a result of exponential cellular proliferation and in atherosclerotic diseases as a result of inefficient blood supply," according to researchers in Israel.
"Hypoxia-inducible factor 1 (HIF-1) is central in normal angiogenesis and cancer angiogenesis. HIF-1 is a transcriptional activator composed of an O2 - and growth factor-regulated HIF-1alpha subunit and a constitutively expressed HIF-1beta subunit," noted S.A.M. Paul and colleagues, Tel Aviv Sourasky Medical...
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Source: Cancer Weekly (2004-08-10)
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