Ovarian Cancer

Pathogenic role suggested for eukaryotic initiation factor oncogene

Published in Cancer Weekly, August 17th, 2004

A member of eukaryotic initiation factor 5A subfamily may be involved in the pathogenesis of ovarian cancer, according to a study from the People's Republic of China.

"Amplification of 3q26 is one of the most frequent chromosomal alterations in many solid tumors, including ovarian, lung, esophageal, prostate, breast, and nasopharyngeal cancers. A candidate oncogene to eukaryotic initiation factor 5A2 (eIF-5A2), a member of eukaryotic initiation factor 5A subfamily, has been isolated from a frequently amplified region at 3q26.2," said X.Y. Guan and colleagues, University of Hong Kong.

These researchers found evidence of eIF-5A2's tumorigenic ability...

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Source: Cancer Weekly (2004-08-17)

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