Breast Cancer
Steroid sulfatase inhibitors inhibit MCF-7 breast cancer cell gene activation
Published in Cancer Weekly, August 17th, 2004
According to recent research published in the Journal of Steroid Biochemistry and Molecular Biology, "A number of 2-phenylindole sulfamates with lipophilic side chains in 1- or 5-position of the indole were synthesized and evaluated as steroid sulfatase (estrone sulfatase) inhibitors.
"Most of the new sulfamates inhibited the enzymatic hydrolysis of estrone sulfate in MDA-MB 231 breast cancer cells with IC50 values between 2 nM and 1 mcM.
"A favorable position for a long side chain is the nitrogen of a carbamoyl group at C-5 of the...
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Source: Cancer Weekly (2004-08-17)
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