Brain Cancer

Childhood brain cancer linked to deletion of a Hedgehog pathway suppressor

Published in Cancer Weekly, August 17th, 2004

A new study supports Hedgehog pathway inhibition as potential therapeutic approach to treatment of human medulloblastoma.

Curis, Inc., (CRIS), a therapeutic drug development company, announced that the current online issue of the Proceedings of the National Academy of Sciences of the United States of America contains a study report demonstrating that human medulloblastoma, the most common childhood brain malignancy, is strongly correlated with deletion of a gene that encodes a suppressor of the Hedgehog signaling pathway.

The authors suggest elimination of this suppressor results in abnormal activation of the Hedgehog pathway, thus promoting...

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Source: Cancer Weekly (2004-08-17)

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