DNA Analysis

Quadruplex regulates expression of c-Myc oncogene, adopts parallel-loop isomers

Published in Cancer Weekly, August 17th, 2004

Cylene Pharmaceuticals and its collaborators at the University of Arizona announced the publication of an article that provides evidence that a quadruplex that regulates expression of the c-Myc oncogene can adopt different parallel-loop isomers.

Findings were published in the Journal of the American Chemical Society (Vol. 126, No. 28) and entitled, "The Dynamic Character of the G-Quadruplex Element in the c-MYC Promoter and Modification by TMPyP4," (J.Seenisamy, et. al.).

To better understand the structural basis for drug-induced lowering of c-Myc gene expression, a quadruplex-forming DNA sequence in the regulatory region of the c-Myc oncogene...

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Source: Cancer Weekly (2004-08-17)

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